Self-Healing Hydrogels of Low Molecular Weight Poly(vinyl alcohol) Assembled by Host-Guest Recognition

被引：74

作者：

Jia, Yong-Guang ^{[1
]}

Jin, Jiahong ^{[1
]}

Liu, Sa ^{[1
]}

Ren, Li ^{[1
]}

Luo, Juntao ^{[2
]}

Zhu, X. X. ^{[3
]}

机构：

[1] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China

[2] SUNY Upstate Med Univ, Dept Pharmacol, Syracuse, NY 13210 USA

[3] Univ Montreal, Dept Chim, CP 6128, Montreal, PQ H3C 3J7, Canada

来源：

BIOMACROMOLECULES | 2018年 / 19卷 / 02期

基金：

加拿大自然科学与工程研究理事会; 中国国家自然科学基金;

关键词：

HYALURONIC-ACID HYDROGELS; CROSS-LINKING; SUPRAMOLECULAR HYDROGEL; INCLUSION COMPLEXES; CHOLIC-ACID; CARTILAGE; POLYMERS; CYCLODEXTRINS; RESPONSIVENESS; DERIVATIVES;

D O I：

10.1021/acs.biomac.7b01707

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(vinyl alcohol) (PVA) is a cytocompatible synthetic polymer and has been commonly used to prepare hydrogels. Bile acids and beta-cyclodextrin are both natural compounds and they form stable host-guest inclusion complexes. They are attached covalently onto a low molecular weight PVA separately. Self-healing hydrogels can be easily formed by mixing the aqueous solutions of these PVA based polymers. The mechanical properties of the hydrogels can be tuned by varying the molar fractions of bile acid units on PVA. The dynamic inclusion complexation of the host-guest pair of the hydrogel allows the self-healing rapidly under ambient atmosphere and their mechanical properties could recover their original values in 1 min after incision. These PVA based polymers exhibited the good cytocompatibility and high hemocompatibility as shown by their biological evaluations. The use of natural compounds for host-guest interaction make such gels especially convenient to use as biomaterials, an advantage over conventional hydrogels prepared through freeze-thaw method.

引用

页码：626 / 632

页数：7

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