2,3-Disubstituted benzofuran and indole by copper-mediated C-C bond extension reaction of 3-zinciobenzoheterole

被引：155

作者：

Nakamura, Masaharu ^{[1
]}

Ilies, Laurean ^{[1
]}

Otsubo, Saika ^{[1
]}

Nakamura, Eiichi ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 13期

关键词：

D O I：

10.1021/ol060896y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metalative 5-endo-dig cyclization reaction of 2-ynylphenoles or anilines effected by BuLi and ZnCl2 produces 3-zinciobenzoheteroles in excellent yield. These intermediates have been transmetalated to the corresponding cuprates and allowed to react with electrophiles to produce a variety of 2,3-disubstituted benzofurans and indoles.

引用

页码：2803 / 2805

页数：3

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