Upconversion Nanoparticles For Photodynamic Therapy

被引：0
|
作者：
Tokatli-Apollon, Amira [1 ,2 ]
Lee, Hyungseok [1 ,2 ]
El-rifai, Mahmoud [1 ,2 ]
Punjabi, Amol [1 ]
Wu, Xiang [1 ]
Han, Gang [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Amherst, MA 01003 USA
[2] Worcester Polytech Inst, Dept Biomed Engn, Worcester, MA 01609 USA
来源：
2014 40TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC) | 2014年
关键词：
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In order to establish a noninvasive cancer therapy with minimal side effects, low cost, and specific in targeting tumor cells. The team engineered novel and biocompatible Upconversion Nanoparticles (UCNPs) with a calcium fluoride shell alpha-NaYF4:Yb,Er@CaF2 and conjugated with an FDA approved prodrug 5-Aminolevulinic Acid (ALA). In conjunction with photodynamic therapy (PDT), deep tissue penetration was achieved. UCNPs convert near-infrared light into visible light when excited at similar to 980nm. Emission of the red light from the UCNPs activate the photosensitizer protoporphyrin (PpIX), causing the production of reactive oxygen species (ROS) causing the death of targeted tumor.
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