Hyperandrogenism after transfer of topical testosterone gel: case report and review of published and unpublished studies

被引:68
作者
de Ronde, Willem [1 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, NL-1007 MB Amsterdam, Netherlands
关键词
NORMALIZES ANDROGEN LEVELS; SEXUAL FUNCTION; BODY-COMPOSITION; HYPOGONADAL MEN; IMPROVEMENTS; VIRILIZATION; EXPOSURE;
D O I
10.1093/humrep/den372
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Topically applied testosterone gels are a widely used mode of testosterone replacement therapy. A concern associated with the use of testosterone gel is unintentional transfer to children or women by skin contact with the application site. We present a case of female hyperandrogenism most likely caused by transfer of testosterone gel used by her partner. Additionally, we searched the computerized database PUBMED and the FDA medical reviews for case reports and clinical trials concerning transfer risk. Several case reports and the results of clinical trials indicate that transfer of testosterone from gel-treated males to women and children is possible and clinically relevant. Thus, the potential of testosterone transfer in gel users should be recognized as a possible side effect of this form of testosterone replacement therapy.
引用
收藏
页码:425 / 428
页数:4
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