Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [11C]ABP688 and Magnetic Resonance Spectroscopy
被引:58
作者:
Martinez, Diana
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机构:
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Martinez, Diana
[1
,2
]
Slifstein, Mark
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机构:
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Slifstein, Mark
[1
,2
]
Nabulsi, Nabeel
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h-index: 0
机构:
Yale Univ, Sch Med, Dept Psychiat, Yale Positron Emiss Tomog Ctr, New Haven, CT USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Nabulsi, Nabeel
[3
]
Grassetti, Alexander
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h-index: 0
机构:
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Grassetti, Alexander
[1
,2
]
Urban, Nina B. L.
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h-index: 0
机构:
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Urban, Nina B. L.
[1
,2
]
Perez, Audrey
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h-index: 0
机构:
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Perez, Audrey
[1
,2
]
Liu, Fei
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h-index: 0
机构:
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Liu, Fei
[1
,2
]
Lin, Shu-Fei
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h-index: 0
机构:
Yale Univ, Sch Med, Dept Psychiat, Yale Positron Emiss Tomog Ctr, New Haven, CT USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Lin, Shu-Fei
[3
]
Ropchan, Jim
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h-index: 0
机构:
Yale Univ, Sch Med, Dept Psychiat, Yale Positron Emiss Tomog Ctr, New Haven, CT USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Ropchan, Jim
[3
]
Mao, Xiangling
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h-index: 0
机构:
Cornell Univ, Dept Radiol, Weill Med Coll, New York, NY 10021 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Mao, Xiangling
[4
]
Kegeles, Lawrence S.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
New York State Psychiat Inst & Hosp, New York, NY 10032 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Kegeles, Lawrence S.
[1
,2
]
Shungu, Dikoma C.
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Radiol, Weill Med Coll, New York, NY 10021 USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Shungu, Dikoma C.
[4
]
Carson, Richard E.
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h-index: 0
机构:
Yale Univ, Sch Med, Dept Psychiat, Yale Positron Emiss Tomog Ctr, New Haven, CT USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Carson, Richard E.
[3
]
Huang, Yiyun
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Psychiat, Yale Positron Emiss Tomog Ctr, New Haven, CT USAColumbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
Huang, Yiyun
[3
]
机构:
[1] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[3] Yale Univ, Sch Med, Dept Psychiat, Yale Positron Emiss Tomog Ctr, New Haven, CT USA
[4] Cornell Univ, Dept Radiol, Weill Med Coll, New York, NY 10021 USA
Background: Preclinical studies demonstrate that glutamate homeostasis in the striatum is disrupted following cocaine exposure, including a decrease in metabotropic glutamate receptor type 5 (mGluR5) expression and reduced glutamate turnover. The goal of this study was to use imaging of the human brain to investigate alterations in the glutamate signaling in cocaine addiction. Methods: Positron emission tomography imaging with the radiotracer [C-11]ABP688 was used to measure mGluR5 binding and magnetic resonance spectroscopy was used to measure glutamate-glutamine levels in the striatum of cocaine-addicted participants (n=15) compared with healthy control subjects (n=15). Following the scans, the cocaine-addicted volunteers performed cocaine self-administration sessions to investigate the correlation between cocaine-seeking behavior and mGluR5 receptor binding. Results: The results of the study showed that cocaine addiction was associated with a 20% to 22% reduction in [C-11]ABP688 binding in the striatum. A secondary analysis of cortical and subcortical regions other than the striatum showed a similar reduction in [C-11]ABP688 binding, suggesting that the decrease was widespread. No between-group differences were seen in the magnetic resonance spectroscopy measures of glutamate-glutamine in the left striatum. In addition, no correlation was seen between [C-11]ABP688 binding in the striatum and the choice to self-administer cocaine. Conclusions: Overall, these results show that long-term cocaine use is associated with a decrease in mGluR5 availability compared with matched healthy control subjects and suggests that this receptor may serve as a viable target for treatment development for this disorder.
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Ben-Shahar, Osnat
;
Obara, Ilona
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA
Polish Acad Sci, Inst Pharmacol, Dept Pain Pharmacol, PL-31343 Krakow, PolandUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Obara, Ilona
;
Ary, Alexis W.
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Ary, Alexis W.
;
Ma, Natalie
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Ma, Natalie
;
Mangiardi, Mario A.
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机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Mangiardi, Mario A.
;
Medina, Robert L.
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Medina, Robert L.
;
Szumlinski, Karen K.
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
机构:
New York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
DeLorenzo, Christine
;
Kumar, J. S. Dileep
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h-index: 0
机构:
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USA
Columbia Univ, Dept Radiol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
Kumar, J. S. Dileep
;
Mann, J. John
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h-index: 0
机构:
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USA
Columbia Univ, Dept Radiol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
Mann, J. John
;
Parsey, Ramin V.
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h-index: 0
机构:
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Ben-Shahar, Osnat
;
Obara, Ilona
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA
Polish Acad Sci, Inst Pharmacol, Dept Pain Pharmacol, PL-31343 Krakow, PolandUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Obara, Ilona
;
Ary, Alexis W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Ary, Alexis W.
;
Ma, Natalie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Ma, Natalie
;
Mangiardi, Mario A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Mangiardi, Mario A.
;
Medina, Robert L.
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Medina, Robert L.
;
Szumlinski, Karen K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA
机构:
New York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
DeLorenzo, Christine
;
Kumar, J. S. Dileep
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USA
Columbia Univ, Dept Radiol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
Kumar, J. S. Dileep
;
Mann, J. John
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USA
Columbia Univ, Dept Radiol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA
Mann, J. John
;
Parsey, Ramin V.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Psychiat, Div Mol Imaging & Neuropathol, New York, NY USANew York State Psychiat Inst & Hosp, Unit 42, New York, NY 10032 USA