Effect of bioactive glass/cement weight ratio on bioactivity and biocompatibility of a bioactive glass modified glass ionomer cement

The bioactivity of a glass ionomer luting cement (Ketac((R))-cem, ESPE, Germany), which was modified by Bioglass((R)) (PerioGlas((R)) Synthetic Bone Graft Particulate, US Biomaterials) in different bioglass/powder weight ratios, and the biocompatibility of the produced mixtures were evaluated in this study using different cell lines. The incorporation of Bioglass((R)) in the cement structure resulted in the formation of sparsely located biological apatite aggregations. However, although Bioglass((R)) incorporation seemed to enhance cell proliferation, the materials became eventually brittle and highly soluble depending on Bioglass((R)) amount.