Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders

被引：33

作者：

Tamura, Kazuo ^{[1
]}

Urabe, Akio ^{[2
]}

Yoshida, Minoru ^{[3
]}

Kanamaru, Akihisa ^{[4
]}

Kodera, Yoshihisa ^{[5
]}

Okamoto, Shinichiro ^{[6
]}

Maesaki, Shigefumi ^{[7
]}

Masaoka, Tohru ^{[8
]}

机构：

[1] Fukuoka Univ, Sch Med, Dept Internal Med, Jonan Ku, Fukuoka 8140180, Japan

[2] Kanto Med Ctr NTT EC, Ctr Prevent Med, Shinagawa Ku, Tokyo, Japan

[3] Teikyo Univ, Sch Med, Mizonokuchi Hosp, Dept Internal Med 4,Takatsu Ku, Kawawsaki, Japan

[4] Kinki Univ, Sch Med, Dept Hematol, Ohno Higashi, Osakasayama, Japan

[5] Japan Red Cross Nagoya First Hosp, Dept Hematol, Nakamura Ku, Nagoya, Aichi, Japan

[6] Keio Univ, Sch Med, Dept Internal Med, Div Hematol, Tokyo, Japan

[7] Saitama Med Univ Hosp, Dept Infect Dis & Infect Control, Iruma, Saitama, Japan

[8] Osaka Med Ctr Canc & Cardiovasc Dis, Higashinari Ku, Osaka, Japan

来源：

LEUKEMIA & LYMPHOMA | 2009年 / 50卷 / 01期

关键词：

Micafungin; echinocandin; fungal infection; febrile neutropenia; empirical therapy; hematological disorders; LIPOSOMAL AMPHOTERICIN-B; FEBRILE NEUTROPENIC PATIENTS; STEM-CELL TRANSPLANTATION; PERSISTENT FEVER; EMPIRICAL THERAPY; DOUBLE-BLIND; OPEN-LABEL; FK463; VORICONAZOLE; CASPOFUNGIN;

D O I：

10.1080/10428190802635500

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The study was conducted as a prospective multicenter trial to evaluate the efficacy and safety of micafungin in patients with invasive fungal infections (IFIs) in hematological disorders. A total of 277 patients was registered, and 197 were assessed for clinical efficacy. The mean dosage and duration of micafungin were 170.7mg/day and 22.0 days, respectively. The efficacy rates were 87.5% (7/8) for patients with candidiasis, 44.7% (17/38) for probable IFIs, 61.9% (39/63) for possible IFIs and 80.7% (71/88) for those who failed to respond to antibacterials. In patients with febrile neutropenia (below 500L), despite broad-spectrum antibacterial treatment over 2 days, 86.3% (44/51) of patients had a favourable response to micafungin. The incidence of adverse events related to micafungin was 14.1% (39/277), but most of them were mild and reversible. These data indicate the usefulness of micafungin as a novel therapeutic drug for both empirical and targeted therapy for IFIs.

引用

页码：92 / 100

页数：9

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