Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
被引:106
作者:
Pearson, Ryan M.
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机构:
Univ Illinois, Dept Biopharmaceut Sci, 833 S Wood St,Rm 335, Chicago, IL 60612 USAUniv Illinois, Dept Biopharmaceut Sci, 833 S Wood St,Rm 335, Chicago, IL 60612 USA
Pearson, Ryan M.
[1
]
Juettner, Vanessa V.
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机构:
Univ Illinois, Dept Biopharmaceut Sci, 833 S Wood St,Rm 335, Chicago, IL 60612 USAUniv Illinois, Dept Biopharmaceut Sci, 833 S Wood St,Rm 335, Chicago, IL 60612 USA
Juettner, Vanessa V.
[1
]
Hong, Seungpyo
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机构:
Univ Illinois, Dept Biopharmaceut Sci, 833 S Wood St,Rm 335, Chicago, IL 60612 USA
Univ Illinois, Dept Bioengn, Chicago, IL USAUniv Illinois, Dept Biopharmaceut Sci, 833 S Wood St,Rm 335, Chicago, IL 60612 USA
Hong, Seungpyo
[1
,2
]
机构:
[1] Univ Illinois, Dept Biopharmaceut Sci, 833 S Wood St,Rm 335, Chicago, IL 60612 USA
nanoparticle;
biomolecular corona;
targeted drug delivery;
in vivo efficacy;
PROTEIN CORONA;
CONFORMATIONAL-CHANGES;
BINDING;
BIODISTRIBUTION;
PLASMA;
SIZE;
NANOCARRIERS;
ACCUMULATION;
TRANSFERRIN;
ADSORPTION;
D O I:
10.3389/fchem.2014.00108
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the "biomolecular" corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.
机构:
Stanford Univ, Dept Pediat, Sch Med, Div Cardiol, Stanford, CA 94305 USAMax Planck Inst Polymer Res, D-55128 Mainz, Germany
Serpooshan, Vahid
;
Sakhtianchi, Ramin
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机构:
Univ Tehran Med Sci, Dept Nanotechnol, Tehran, Iran
Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, IranMax Planck Inst Polymer Res, D-55128 Mainz, Germany
机构:
Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA 02114 USA
MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMassachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
Chauhan, Vikash P.
;
Jain, Rakesh K.
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
机构:
Stanford Univ, Dept Pediat, Sch Med, Div Cardiol, Stanford, CA 94305 USAMax Planck Inst Polymer Res, D-55128 Mainz, Germany
Serpooshan, Vahid
;
Sakhtianchi, Ramin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Dept Nanotechnol, Tehran, Iran
Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, IranMax Planck Inst Polymer Res, D-55128 Mainz, Germany
机构:
Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA 02114 USA
MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMassachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
Chauhan, Vikash P.
;
Jain, Rakesh K.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA