Differential expression of bovine major acute phase proteins, cytokines and metabolic indicator genes in clinical endometritis cows

被引：0
作者：
Manimaran, Ayyasamy [1 ,2 ]
Kumaresan, Arumugam [1 ,2 ]
Sarkar, Souvendra Nath [1 ,3 ]
Boya, Sanjanna [1 ,4 ]
Sreela, L. [1 ,4 ]
Mooventhan, P. [1 ,4 ]
Wankhade, Pratik R. [1 ,4 ]
机构：
[1] ICAR Natl Dairy Res Inst, Karnal 132001, Haryana, India
[2] ICAR Natl Dairy Res Inst, LRC, SRS, Bengaluru, Karnataka, India
[3] ICAR Indian Vet Res Inst, Div Pharmacol, Izatnagar, Uttar Pradesh, India
[4] ICAR Natl Inst Biot Stress Management, Raipur, Chhattisgarh, India
来源：
INDIAN JOURNAL OF ANIMAL SCIENCES | 2019年 / 89卷 / 04期
关键词：
Acute phase proteins; Clinical endometritis; Cows; Energy indicators; Gene expression; Pro-inflammatory cytokines; ENERGY-BALANCE; IMMUNE-RESPONSES; EPITHELIAL-CELLS; POSTPARTUM; ELEMENTS; BLOOD; CYCLE;
D O I：
暂无
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Among the uterine diseases, clinical endometritis (CE) is a major challenge to livestock farming as it causes sub-or infertility problems in dairy animals. The aim of this study was to evaluate the expression of cytokines (IL-1 beta, TNF-alpha, IL-6, and IL-8), acute phase proteins [APPs; haptoglobin (Hp), serum amyloid A (SAA) and alpha-1 acid glycoprotein (AGP)] and energy indicators [leptin and insulin-like growth factor (IGF)-1] genes in uterine tissue of CE affected cows. The uterine biopsy from CE cows (4) and non-endometritis cows (4) was processed for quantitative real-time PCR to study the mRNA expression of these innate immune molecules. We observed that mRNA expression of SAA, IL-1 beta, IL-8 and leptin genes were significantly up-regulated while, TNF-alpha and IGF-I genes were significantly down-regulated in CE cows. It can be concluded that bovine APPs, cytokines and energy indicators genes are differentially expressed in CE affected cows.
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收藏
页码：402 / 406
页数：5
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