Curcumin improves spatial memory and decreases oxidative damage in aged female rats

被引：54
作者：
Belviranli, Muaz [1 ]
Okudan, Nilsel [1 ]
Atalik, Kismet Esra Nurullahoglu [2 ]
Oz, Mehmet [1 ]
机构：
[1] Selcuk Univ, Dept Physiol, Fac Med, Konya, Turkey
[2] Necmettin Erbakan Univ, Dept Pharmacol, Meram Fac Med, Konya, Turkey
来源：
BIOGERONTOLOGY | 2013年 / 14卷 / 02期
关键词：
Curcumin; Aging; Spatial learning; Memory; Oxidative stress; INDUCED COGNITIVE IMPAIRMENT; FOCAL CEREBRAL-ISCHEMIA; MORRIS WATER MAZE; ALZHEIMERS-DISEASE; OVARIAN HORMONES; STRESS; PERFORMANCE; BRAIN; SUPPLEMENTATION; OVARIECTOMY;
D O I：
10.1007/s10522-013-9422-y
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging induced cognitive impairment has been well documented for many years and several antioxidant strategies have been developed against this impairment. Curcumin is the active component of curcuma longa and has shown antioxidant, antiinflamatory and neuroprotective properties. We hypothesized that curcumin would have an influence on cognitive functions in aged female rats. The purpose of the present study was to investigate the effects of curcumin supplementation on cognitive impairment evaluated by Morris water maze (MWM) as well as the oxidative stress induced by aging in female rats. Rats were randomly divided into either control or curcumin-supplemented groups. Curcumin or vehicle (corn oil) were given once daily for a period of 12 days, beginning 7 days prior to and 5 days during the behavioral tests. Behavioral assessment was performed in MWM. At the end of the behavioral test, blood samples and brain tissues were taken for the analysis of malondialdeyde (MDA), protein carbonyl and glutathione levels. During the training session, curcumin supplementation decreased latency to reach to the platform and the total distance traveled. During the probe trial, curcumin supplementation increased the number of platform crossings. In addition to the behavioral testing, biochemical results showed that MDA levels decreased in brain tissue by curcumin supplementation. It may be concluded that, curcumin supplementation improves cognitive functions by decreasing the lipid peroxidation in brain tissue of aged female rats.
引用
收藏
页码：187 / 196
页数：10
相关论文
共 50 条
[41]   Daily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats [J].
Thangthaeng, Nopporn ;
Miller, Marshall G. ;
Gomes, Stacey M. ;
Shukitt-Hale, Barbara .
NUTRITION RESEARCH, 2015, 35 (12) :1079-1084
[42]   Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats [J].
Thangthaeng, Nopporn ;
Poulose, Shibu M. ;
Gomes, Stacey M. ;
Miller, Marshall G. ;
Bielinski, Donna F. ;
Shukitt-Hale, Barbara .
AGE, 2016, 38 (5-6) :393-404
[43]   Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats [J].
Leite, Marlon Regis ;
Wilhelm, Ethel A. ;
Jesse, Cristiano R. ;
Brandao, Ricardo ;
Nogueira, Cristina Wayne .
EXPERIMENTAL GERONTOLOGY, 2011, 46 (04) :309-315
[44]   Galantamine effects on memory, spatial cue utilization, and neurotrophic factors in aged female rats [J].
French, K. L. ;
Bimonte-Nelson, H. A. ;
Granholm, A. -Ch. .
CELL TRANSPLANTATION, 2007, 16 (03) :197-205
[45]   Sodium butyrate improves memory and modulates the activity of histone deacetylases in aged rats after the administration of D-galactose [J].
Garcez, Michelle Lima ;
de Carvalho, Carlos Alberto ;
Mina, Francielle ;
Bellettini-Santos, Tatiani ;
Schiavo, Gustavo Luis ;
da Silva, Sabrina ;
Falchetti Campos, Ana Carolina Brunatto ;
Varela, Roger Bitencourt ;
Valvassori, Samira S. ;
Damiani, Adriani Paganini ;
Longaretti, Luiza Martins ;
de Andrade, Vanessa Moraes ;
Budni, Josiane .
EXPERIMENTAL GERONTOLOGY, 2018, 113 :209-217
[46]   Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats [J].
Cardoso, Fabrizio dos Santos ;
Franca, Erivelton Fernandes ;
Serra, Fernando Tadeu ;
Victorino, Angelica Begatti ;
de Almeida, Alexandre Aparecido ;
Fernandes, Jansen ;
Cabral, Francisco Romero ;
Venancio, Daniel Paulino ;
Arida, Ricardo Mario ;
da Silva, Sergio Gomes .
HIPPOCAMPUS, 2017, 27 (08) :899-905
[47]   Repeated ethanol exposure affects the acquisition of spatial memory in adolescent female rats [J].
Sircar, Ratna ;
Basak, Ashim K. ;
Sircar, Debashish .
BEHAVIOURAL BRAIN RESEARCH, 2009, 202 (02) :225-231
[48]   Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats [J].
Reeta, K. H. ;
Mehla, Jogender ;
Gupta, Yogendra Kumar .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 644 (1-3) :106-112
[49]   Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats [J].
Taridi, N. M. ;
Yahaya, M. F. ;
Teoh, S. L. ;
Latiff, A. A. ;
Ngah, W. Z. Wan ;
Das, S. ;
Mazlan, M. .
CLINICA TERAPEUTICA, 2011, 162 (02) :93-98
[50]   Chronic NaHS treatment improves spatial and passive avoidance learning and memory and anxiety-like behavior and decreases oxidative stress in rats fed with a high-fat diet [J].
Habibitabar, Elahe ;
Moridi, Heresh ;
Shateri, Hossein ;
Karimi, Seyed Asaad ;
Salehi, Iraj ;
Komaki, Alireza ;
Sarihi, Abdolrahman .
BRAIN RESEARCH BULLETIN, 2020, 164 :380-391
12345