MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2

被引：139

作者：

Li, Juan ^{[1
]}

Du, Lutao ^{[1
]}

Yang, Yongmei ^{[1
]}

Wang, Chuanxin ^{[1
]}

Liu, Hui ^{[1
]}

Wang, Lili ^{[1
]}

Zhang, Xin ^{[1
]}

Li, Wei ^{[1
]}

Zheng, Guixi ^{[1
]}

Dong, Zhaogang ^{[1
]}

机构：

[1] Shandong Univ, Dept Clin Lab, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

来源：

CANCER LETTERS | 2013年 / 329卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Colorectal cancer; MiR-429; Prognosis; Apoptosis; SOX2; MICRORNA; EXPRESSION; PLURIPOTENCY;

D O I：

10.1016/j.canlet.2012.10.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Emerging evidence has demonstrated that microRNAs (miRNAs) can act as oncogenes or tumor suppressors to participate in cancer development. In this study, we found that miR-429 expression was up-regulated in human colorectal cancer (CRC) tissues, and the high miR-429 expression was significantly associated with tumor size, lymph node metastasis and poor prognosis. Functionally, miR-429 overexpression suppressed cell apoptosis by directly targeting SOX2 in HT-29 cells. Taken together, our data suggest for the first time that miR-429 could play an oncogenic role in the cellular processes of CRC and represent a novel prognostic biomarker for CRC. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：84 / 90

页数：7

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