Polyphenols attached graphene nanosheets for high efficiency NIR mediated photodestruction of cancer cells

被引：70

作者：

Abdolahad, M. ^{[1
,4
]}

Janmaleki, M. ^{[2
]}

Mohajerzadeh, S. ^{[1
,4
]}

Akhavan, O. ^{[3
]}

Abbasi, S. ^{[2
]}

机构：

[1] Univ Tehran, Nanoelect & Thin Film Lab, Nanoelect Ctr Excellence, Sch Elect & Comp Engn, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Med Nanotechnol & Tissue Engn Res Ctr, Tehran, Iran

[3] Sharif Univ Technol, Dept Phys, Inst Nanosci & Nanotechnol, Tehran, Iran

[4] Univ Tehran, Tehran, Iran

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 03期

关键词：

Graphene; Near IR; Cancer cell; Photothermal therapy; Green tea; Polyphenol; CARBON NANOTUBES; GREEN REDUCTION; SINGLE-LAYER; OXIDE; FILMS; TEA; NANOPARTICLES; MECHANISMS; GRAPHITE; SHEETS;

D O I：

10.1016/j.msec.2012.12.052

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Green tea-reduced graphene oxide (GT-rGO) sheets have been exploited for high efficiency near infrared (NIR) photothermal therapy of HT29 and SW48 colon cancer cells. The biocompatibility of GT-rGO sheets was investigated by means of MTT assays. The polyphenol constituents of GT-rGO act as effective targeting ligands for the attachment of rGO to the surface of cancer cells, as confirmed by the cell granularity test in flow cytometry assays and also by scanning electron microscopy. The photo-thermal destruction of higher metastatic cancer cells (SW48) is found to be more than 20% higher than that of the lower metastatic one (HT29). The photo-destruction efficiency factor of the GT-rGO is found to be at least two orders of magnitude higher than other carbon-based nano-materials. Such excellent cancer cell destruction efficiency provided application of a low concentration of rGO (3 mg/L) and NIR laser power density (0.25 W/cm(2)) in our photo-thermal therapy of cancer cells. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1498 / 1505

页数：8

共 67 条

[1] Wrapping Bacteria by Graphene Nanosheets for Isolation from Environment, Reactivation by Sonication, and Inactivation by Near-Infrared Irradiation [J].

Akhavan, O. ;

Ghaderi, E. ;

Esfandiar, A. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (19) :6279-6288

[2] Photocatalytic reduction of graphene oxides hybridized by ZnO nanoparticles in ethanol [J].

Akhavan, O. .

CARBON, 2011, 49 (01) :11-18

[3] Photodegradation of Graphene Oxide Sheets by TiO2 Nanoparticles after a Photocatalytic Reduction [J].

Akhavan, O. ;

Abdolahad, M. ;

Esfandiar, A. ;

Mohatashamifar, M. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (30) :12955-12959

[4] The effect of heat treatment on formation of graphene thin films from graphene oxide nanosheets [J].

Akhavan, O. .

CARBON, 2010, 48 (02) :509-519

[5] Photocatalytic Reduction of Graphene Oxide Nanosheets on TiO2 Thin Film for Photoinactivation of Bacteria in Solar Light Irradiation [J].

Akhavan, O. ;

Ghaderi, E. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (47) :20214-20220

[6] Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria [J].

Akhavan, Omid ;

Ghaderi, Elham .

ACS NANO, 2010, 4 (10) :5731-5736

[7] Graphene Nanomesh by ZnO Nanorod Photocatalysts [J].

Akhavan, Omid .

ACS NANO, 2010, 4 (07) :4174-4180

[8] Graphene-like nano-sheets for surface acoustic wave gas sensor applications [J].

Arsat, R. ;

Breedon, M. ;

Shafiei, M. ;

Spizziri, P. G. ;

Gilje, S. ;

Kaner, R. B. ;

Kalantar-Zadeh, K. ;

Wlodarski, W. .

CHEMICAL PHYSICS LETTERS, 2009, 467 (4-6) :344-347

[9]

Bai JW, 2010, NAT NANOTECHNOL, V5, P190, DOI [10.1038/NNANO.2010.8, 10.1038/nnano.2010.8]

[10]

Beltz Lisa Ann, 2006, Anti-Cancer Agents in Medicinal Chemistry, V6, P389

← 1 2 3 4 5 6 7 →