Optimization of Pressurized Liquid Extraction of Three Major Acetophenones from Cynanchum bungei Using a Box-Behnken Design

被引：13
作者：
Li, Wei [2 ]
Zhao, Li-Chun [1 ]
Sun, Yin-Shi [3 ]
Lei, Feng-Jie [2 ]
Wang, Zi [2 ]
Gui, Xiong-Bin [1 ]
Wang, Hui [4 ]
机构：
[1] Guangxi Univ Chinese Med, Affiliated Ruikang Hosp, Nanning 530011, Peoples R China
[2] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
[3] Shandong Agr Univ, Coll Agron, Tai An 271018, Shandong, Peoples R China
[4] Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 11期
关键词：
pressurized liquid extraction; acetophenones; Cynanchum bungei Decne; Box-Behnken design; response surface methodology; RESPONSE-SURFACE METHODOLOGY; ASSISTED EXTRACTION; FATTY-ACIDS; 4; CHROMONES; CHROMATOGRAPHY; BAISHOUWU; SAPONINS; PURIFICATION; PLANTS; HPLC;
D O I：
10.3390/ijms131114533
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this work, pressurized liquid extraction (PLE) of three acetophenones (4-hydroxyacetophenone, baishouwubenzophenone, and 2,4-dihydroxyacetophenone) from Cynanchum bungei (ACB) were investigated. The optimal conditions for extraction of ACB were obtained using a Box-Behnken design, consisting of 17 experimental points, as follows: Ethanol (100%) as the extraction solvent at a temperature of 120 C and an extraction pressure of 1500 psi, using one extraction cycle with a static extraction time of 17 min. The extracted samples were analyzed by high-performance liquid chromatography using an UV detector. Under this optimal condition, the experimental values agreed with the predicted values by analysis of variance. The ACB extraction yield with optimal PLE was higher than that obtained by soxhlet extraction and heat-reflux extraction methods. The results suggest that the PLE method provides a good alternative for acetophenone extraction.
引用
收藏
页码：14533 / 14544
页数：12
相关论文
共 28 条
  • [1] Pressurized liquid extraction of capsaicinoids from peppers
    Barbero, Gerardo F.
    Palma, Miguel
    Barroso, Carmelo G.
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (09) : 3231 - 3236
  • [2] Pressurized liquid extraction in the analysis of food and biological samples
    Carabias-Martínez, R
    Rodríguez-Gonzalo, E
    Revilla-Ruiz, P
    Hernández-Méndez, J
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2005, 1089 (1-2) : 1 - 17
  • [3] Development of a sensitive and robust liquid chromatography coupled with tandem mass spectrometry and a pressurized liquid extraction for the determination of aflatoxins and ochratoxin A in animal derived foods
    Chen, Dongmei
    Cao, Xiaoqin
    Tao, Yanfei
    Wu, Qinghua
    Pan, Yuanhu
    Huang, Lingli
    Wang, Xu
    Wang, Yulian
    Peng, Dapeng
    Liu, Zhenli
    Yuan, Zonghui
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2012, 1253 : 110 - 119
  • [4] Extraction of Volatile Oil from Aromatic Plants with Supercritical Carbon Dioxide: Experiments and Modeling
    Coelho, Jose P.
    Cristino, Ana F.
    Matos, Patricia G.
    Rauter, Amelia P.
    Nobre, Beatriz P.
    Mendes, Rui L.
    Barroso, Joao G.
    Mainar, Ana
    Urieta, Jose S.
    Fareleira, Joao M. N. A.
    Sovova, Helena
    Palavra, Antonio F.
    [J]. MOLECULES, 2012, 17 (09): : 10550 - 10573
  • [5] Murine tyrosinase Inhibitors from Cynanchum bungei and evaluation of in vitro and in vivo depigmenting activity
    Ding, Hsiou-Yu
    Chang, Te-Sheng
    Shen, Hung-Chang
    Tai, Sorgan Shou-Ku
    [J]. EXPERIMENTAL DERMATOLOGY, 2011, 20 (09) : 720 - 724
  • [6] Gao Li-jun, 2005, Zhongguo Zhong Yao Za Zhi, V30, P1352
  • [7] A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants
    Huie, CW
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2002, 373 (1-2) : 23 - 30
  • [8] Optimization of pressurized liquid extraction of five major flavanoids from Lysimachia clethroide
    Jiang, Y.
    Li, P.
    Li, S. P.
    Wang, Y. T.
    Tu, Py.
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 43 (01) : 341 - 345
  • [9] Optimisation of microwave-assisted extraction for functional properties of Vitis coignetiae extract by response surface methodology
    Kim, Hyun-Ku
    Do, Jeong-Ryong
    Lim, Tae-Soo
    Akram, Kashif
    Yoon, Sung-Ran
    Kwon, Joong-Ho
    [J]. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2012, 92 (08) : 1780 - 1785
  • [10] Optimization of pressurized liquid extraction for spicatoside A in Liriope platyphylla
    Kim, Seung Hyun
    Kim, Ho Kyung
    Yang, Eun Sun
    Lee, Ki Yong
    Du Kim, Sang
    Kim, Young Choong
    Sung, Sang Hyun
    [J]. SEPARATION AND PURIFICATION TECHNOLOGY, 2010, 71 (02) : 168 - 172
123