Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases

被引：91

作者：

Goettsch, Claudia ^{[1
]}

Kjolby, Mads ^{[2
,3
,4
]}

Aikawa, Elena ^{[5
,6
]}

机构：

[1] Rhein Westfal TH Aachen, Dept Internal Med Cardiol 1, Aachen, Germany

[2] Danish Diabet Acad, Danish Res Inst Translat Neurosci, Nord European Mol Biol Lab Partnership Mol Med, Odense, Denmark

[3] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[4] Aarhus Univ, Dept Cardiol, Aarhus, Denmark

[5] Harvard Med Sch, Brigham & Womens Hosp, Ctr Interdisciplinary Cardiovasc Sci, 3 Blackfan Cir,CLSB,17th Floor, Boston, MA 02115 USA

[6] Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Ctr Excellence Vasc Biol, Boston, MA USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2018年 / 38卷 / 01期

基金：

美国国家卫生研究院;

关键词：

atherosclerosis; cardiovascular disease; clinical study; metabolic disease; morbidity; GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; SUBTILISIN/KEXIN TYPE 9; DENSITY-LIPOPROTEIN CHOLESTEROL; STATIN-NAIVE PATIENTS; MYOCARDIAL-INFARCTION; RECEPTOR SORTILIN; DEGRADATION; SORT1; RISK;

D O I：

10.1161/ATVBAHA.117.310292

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease is a leading cause of morbidity and mortality in the Western world. Studies of sortilin's influence on cardiovascular and metabolic diseases goes far beyond the genome-wide association studies that have revealed an association between cardiovascular diseases and the 1p13 locus that encodes sortilin. Emerging evidence suggests a significant role of sortilin in the pathogenesis of vascular and metabolic diseases; this includes type II diabetes mellitus via regulation of insulin resistance, atherosclerosis through arterial wall inflammation and calcification, and dysregulated lipoprotein metabolism. Sortilin is also known for its functional role in neurological disorders. It serves as a key receptor for cytokines, lipids, and enzymes and participates in pathological cargo loading to and trafficking of extracellular vesicles. This article provides a comprehensive review of sortilin's contributions to cardiovascular and metabolic diseases but focuses particularly on atherosclerosis. We summarize recent clinical findings that suggest that sortilin may be a cardiovascular risk biomarker and also discuss sortilin as a potential drug target.

引用

页码：19 / 25

页数：7

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