Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer

被引：168

作者：

Liu, Zekun ^{[1
]}

Zhao, Qi ^{[1
,2
]}

Zuo, Zhi-Xiang ^{[1
]}

Yuan, Shu-Qiang ^{[1
]}

Yu, Kai ^{[1
]}

Zhang, Qingfeng ^{[1
]}

Zhang, Xiaolong ^{[1
]}

Sheng, Hui ^{[1
]}

Ju, Huai-Qiang ^{[1
]}

Cheng, Han ^{[3
]}

Wang, Feng ^{[1
]}

Xu, Rui-Hua ^{[1
,2
]}

Liu, Ze-Xian ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China

[2] Chinese Acad Med Sci, Precis Diag & Treatment Gastrointestinal Canc, Guangzhou 510060, Peoples R China

[3] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Peoples R China

来源：

ISCIENCE | 2020年 / 23卷 / 07期

基金：

国家重点研发计划;

关键词：

CELL-DEATH; RISK-FACTORS; METABOLISM; GENES; SENSITIVITY; SORAFENIB; RESOURCE; PROTECTS; BIOLOGY; GENOME;

D O I：

10.1016/j.isci.2020.101302

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ferroptosis is a type of cell death related to cancer; however, the characteristics of ferroptosis in cancers are still uncertain. Based on the data in The Cancer Genome Atlas, we found that most ferroptosis regulator genes (FRGs) were differentially expressed in tumors, somatic copy number alterations (SCNA) and DNA methylation contributed to their aberrant expression. We established the ferroptosis potential index (FPI) to reveal the functional roles of ferroptosis and noticed that the FPI was higher in tumors than in normal tissues in most cancers and was associated with subtypes and clinical features. The FPI was negatively correlated with several metabolic pathways but positively associated with several important metastasis-related pathways and immune-related path-ways. High FPI predicted poor prognosis in several tumors, whereas FPI and FRGs impacted drug sensitivity. Our study presents a systematic analysis of ferroptosis and its regulatory genes and highlights the potential of ferroptosis-based cancer therapy.

引用

页数：26

共 56 条

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