An environmentally benign solvent/catalyst-free one-pot synthesis of N-substituted phthalimides via Aza-wittig reaction

被引：10

作者：

Sathishkumar, Murugan ^{[1
]}

Palanikumar, Kulandaivel ^{[1
]}

Mariappan, Arumugam ^{[1
]}

Archana, Sivasubramaniyan ^{[1
]}

Ponnuswamy, Alagusundaram ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2012年 / 9卷 / 05期

关键词：

Phthalic anhydride; Azide; Aza-wittig; Phthalimide; Solvent/catalyst-free; ANTIINFLAMMATORY ACTIVITY; DERIVATIVES; DESIGN; ALKYL;

D O I：

10.1007/s13738-012-0090-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For the first time an environmentally benign solvent/catalyst-free protocol for the synthesis of a variety of N-substituted phthalimides is submitted. It involves a one-pot coupling of nascent phosphazene generated in situ with phthalic anhydride. The protocol is novel in (1) avoiding toxic solvents, (2) no catalyst is employed and (3) no isophthalimide is formed as noted in the prevailing solution phase/catalysed methodology.

引用

页码：681 / 685

页数：5

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