A novel 45 kDa secretory protein from rat olfactory epithelium: primary structure and localisation

被引：29

作者：

Merkulova, MI

Andreeva, SG

Shuvaeva, TM

Novoselov, SV

Peshenko, IV

Bystrova, MF

Novoselov, VI

Fesenko, EE

Lipkin, VM

机构：

[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117871, Russia

[2] Russian Acad Sci, Inst Cell Biophys, Pushchino 142292, Russia

来源：

FEBS LETTERS | 1999年 / 450卷 / 1-2期

基金：

俄罗斯基础研究基金会;

关键词：

45 kDa secretory protein; cDNA cloning; olfactory epithelium; transfer protein;

D O I：

10.1016/S0014-5793(99)00470-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cDNA clones encoding the 45 kDa protein were isolated from a rat olfactory epithelium cDNA library and their inserts were sequenced. The reconstructed protein sequence comprises 400 amino acids with a calculated molecular mass of 46026 Da, A homology mas revealed between the amino acid sequence of the 45 kDa protein and the proteins involved in the transfer of hydrophobic ligands. Using in situ hybridisation, the 45 kDa protein mRNA expression mas detected in the layer of supportive cells of olfactory epithelium, apical region of trachea, surface layer of the ciliated bronchial epithelium in lung and in skin epidermis. (C) 1999 Federation of European Biochemical Societies.

引用

页码：126 / 130

页数：5

共 19 条

[1] MULTIPLE SEQUENCE ALIGNMENT WITH HIERARCHICAL-CLUSTERING [J].