Preparation of Polysaccharide-Based Microspheres by a Water-in-Oil Emulsion Solvent Diffusion Method for Drug Carriers

被引：19

作者：

Baimark, Yodthong ^{[1
]}

Srisuwan, Yaowalak

机构：

[1] Mahasarakham Univ, Fac Sci, Biodegradable Polymers Res Unit, Dept Chem, Maha Sarakham 44150, Thailand

来源：

INTERNATIONAL JOURNAL OF POLYMER SCIENCE | 2013年 / 2013卷

关键词：

CONTROLLED-RELEASE; CHITOSAN MICROSPHERES; HYDROGEL MICROSPHERES; ALGINATE; MICROPARTICLES; CELLULOSE; DELIVERY;

D O I：

10.1155/2013/761870

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polysaccharide-based microspheres of chitosan, starch, and alginate were prepared by the water-in-oil emulsion solvent diffusion method for use as drug carriers. Blue dextran was used as a water-soluble biomacromolecular drug model. Scanning electron microscopy showed sizes of the resultant microspheres that were approximately 100 mu m or less. They were spherical in shape with a rough surface and good dispersibility. Microsphere matrices were shown as a sponge. Drug loading efficiencies of all the microspheres were higher than 80%, which suggested that this method has potential to prepare polysaccharide-based microspheres containing a biomacromolecular drug model for drug delivery applications.

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页数：6

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