Preparation of 6-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-Ones and 2-(Arylamino)Pyrimidines

被引：3

作者：

Terentjeva, S. ^{[1
]}

Muceniece, D. ^{[1
]}

Lusis, V. ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 49卷 / 12期

关键词：

2-(arylamino)pyrimidines; 2-chloropyrimidines; 2-oxo-1,2-dihydropyrimidines; 2-oxo-1,2,3,4-tetrahydropyrimidines; Biginelli reaction; OXIDATIVE DEHYDROGENATION; BIGINELLI; PYRIMIDIN-2(1H)-ONES; DIHYDROPYRIMIDINONES; INHIBITORS; EFFICIENT; POTENT;

D O I：

10.1007/s10593-014-1428-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Biginelli reaction of methyl propiolate and of methyl 3-diethylaminoacrylate has yielded a novel series of 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones. The successie oxidation of the pyrimidine ring, chlorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine give previously unknown 2-(arylamino)pyrimidines. 2-Oxo- and 2-(arylamino)pyrimidine-5-carboxylic acids have been obtained.

引用

收藏

页码：1757 / 1769

页数：13

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