Preparation of 6-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-Ones and 2-(Arylamino)Pyrimidines

被引：3
作者：
Terentjeva, S. [1 ]
Muceniece, D. [1 ]
Lusis, V. [1 ]
机构：
[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 49卷 / 12期
关键词：
2-(arylamino)pyrimidines; 2-chloropyrimidines; 2-oxo-1,2-dihydropyrimidines; 2-oxo-1,2,3,4-tetrahydropyrimidines; Biginelli reaction; OXIDATIVE DEHYDROGENATION; BIGINELLI; PYRIMIDIN-2(1H)-ONES; DIHYDROPYRIMIDINONES; INHIBITORS; EFFICIENT; POTENT;
D O I：
10.1007/s10593-014-1428-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Biginelli reaction of methyl propiolate and of methyl 3-diethylaminoacrylate has yielded a novel series of 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones. The successie oxidation of the pyrimidine ring, chlorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine give previously unknown 2-(arylamino)pyrimidines. 2-Oxo- and 2-(arylamino)pyrimidine-5-carboxylic acids have been obtained.
引用
收藏
页码：1757 / 1769
页数：13
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