Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

被引：5

作者：

Harada, Sohei ^{[1
,2
]}

Aoki, Kotaro ^{[2
]}

Okamoto, Koh ^{[3
]}

Kinoshita, Osamu ^{[4
]}

Nawata, Kan ^{[4
]}

Ishii, Yoshikazu ^{[2
]}

Tateda, Kazuhiro ^{[2
]}

Sasaki, Masakazu ^{[5
]}

Saga, Tomoo ^{[6
]}

Doi, Yohei ^{[1
]}

Yotsuyanagi, Hiroshi ^{[3
]}

Moriya, Kyoji ^{[3
]}

Ono, Minoru ^{[4
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Infect Dis, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan

[2] Toho Univ, Sch Med, Dept Microbiol & Infect Dis, Ota Ku, 5-21-16 Omori Nishi, Tokyo 1438540, Japan

[3] Univ Tokyo, Dept Infect Dis, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[4] Univ Tokyo, Dept Cardiac Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[5] Toho Univ, Omori Med Ctr, Dept Clin Labs, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438541, Japan

[6] Akita Univ Hosp, Cent Lab Div, 1-1-1 Hondo, Akita 0108543, Japan

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2019年 / 84卷

关键词：

Staphylococcus aureus; Left ventricular assist device; Linezolid resistance; Endocarditis; Whole-genome sequencing; IDENTIFICATION; MEC;

D O I：

10.1016/j.ijid.2019.05.001

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The case of a patient with left ventricular assist device (LVAD)-associated endocarditis involving multiple clones of Staphylococcus aureus is presented. Different clones with distinct colony morphology were identified from blood cultures collected on the same day and showed diverse antimicrobial resistance patterns. In addition, a difference in antimicrobial susceptibility was observed even within an identical clone recovered 400 days apart due to the loss of SCCmec for methicillin and modification of the 23S rRNA target site for linezolid during a long-term treatment course. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：44 / 47

页数：4

共 11 条

[1] HYBRIDSPADES: an algorithm for hybrid assembly of short and long reads [J].