Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis

被引：45
作者：
de Jong, BA
Westendorp, RGJ
Eskdale, J
Uitdehaag, BMJ
Huizinga, TWJ
机构：
[1] Leiden Univ, Ctr Med, Dept Rheumatol, NL-2300 RC Leiden, Netherlands
[2] Univ Glasgow, Dept Clin Epidemiol, Glasgow, Lanark, Scotland
[3] Univ Glasgow, Dept Internal Med, Glasgow, Lanark, Scotland
[4] Univ Glasgow, Dept Surg, Glasgow, Lanark, Scotland
[5] VU Med Ctr, Dept Neurol, Amsterdam, Netherlands
来源：
HUMAN IMMUNOLOGY | 2002年 / 63卷 / 04期
关键词：
multiple sclerosis; interleukin-10; immunogenetics; single nucleotide polymorphisms; etiology;
D O I：
10.1016/S0198-8859(02)00369-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.
引用
收藏
页码：281 / 285
页数：5
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