Migrating into the Tumor: a Roadmap for T Cells

被引：242

作者：

van der Woude, Lieke L. ^{[1
,2
]}

Gorris, Mark A. J. ^{[1
]}

Halilovic, Altuna ^{[1
,2
]}

Figdor, Carl G. ^{[1
]}

de Vries, I. Jolanda M. ^{[1
,3
]}

机构：

[1] Radboud Inst Mol Life Sci, Dept Tumor Immunol, Geert Grootepl 26-28, NL-6525 GA Nijmegen, Netherlands

[2] Radboudumc, Dept Pathol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands

[3] Radboudumc, Dept Med Oncol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands

来源：

TRENDS IN CANCER | 2017年 / 3卷 / 11期

关键词：

HIGH ENDOTHELIAL VENULES; HUMAN-MELANOMA METASTASES; HUMAN LUNG-CANCER; LYMPHOID STRUCTURES; ANTITUMOR IMMUNITY; BREAST-CANCER; INDOLEAMINE 2,3-DIOXYGENASE; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; IMMUNOTHERAPY;

D O I：

10.1016/j.trecan.2017.09.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumors can be divided into 'hot' (T cell inflamed) or 'cold' (T cell noninflamed) according to the presence of immune cells. In this review, we discuss variables that influence T cell migration into the tumor microenvironment. Chemokines can attract T cells to the tumor site and tumor intrinsic pathways can influence the composition of local chemokines. Tumor-induced vasculature can hamper T cell migration. Other immune cells and tumor-derived molecules can block T cell proliferation and survival. It is important to better understand these mechanisms in order to target them therapeutically. Enhancing T cell infiltration may increase response rates to immunotherapy and increase survival.

引用

页码：797 / 808

页数：12

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