Migrating into the Tumor: a Roadmap for T Cells

被引：242
作者：
van der Woude, Lieke L. [1 ,2 ]
Gorris, Mark A. J. [1 ]
Halilovic, Altuna [1 ,2 ]
Figdor, Carl G. [1 ]
de Vries, I. Jolanda M. [1 ,3 ]
机构：
[1] Radboud Inst Mol Life Sci, Dept Tumor Immunol, Geert Grootepl 26-28, NL-6525 GA Nijmegen, Netherlands
[2] Radboudumc, Dept Pathol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands
[3] Radboudumc, Dept Med Oncol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands
来源：
TRENDS IN CANCER | 2017年 / 3卷 / 11期
关键词：
HIGH ENDOTHELIAL VENULES; HUMAN-MELANOMA METASTASES; HUMAN LUNG-CANCER; LYMPHOID STRUCTURES; ANTITUMOR IMMUNITY; BREAST-CANCER; INDOLEAMINE 2,3-DIOXYGENASE; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; IMMUNOTHERAPY;
D O I：
10.1016/j.trecan.2017.09.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumors can be divided into 'hot' (T cell inflamed) or 'cold' (T cell noninflamed) according to the presence of immune cells. In this review, we discuss variables that influence T cell migration into the tumor microenvironment. Chemokines can attract T cells to the tumor site and tumor intrinsic pathways can influence the composition of local chemokines. Tumor-induced vasculature can hamper T cell migration. Other immune cells and tumor-derived molecules can block T cell proliferation and survival. It is important to better understand these mechanisms in order to target them therapeutically. Enhancing T cell infiltration may increase response rates to immunotherapy and increase survival.
引用
收藏
页码：797 / 808
页数：12
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