Ether a go-go potassium channels and cancer

被引：87
作者：
Camacho, J [1 ]
机构：
[1] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Pharmacol Sect, Mexico City 07360, DF, Mexico
来源：
CANCER LETTERS | 2006年 / 233卷 / 01期
关键词：
cancer; tumor markers; cervical cancer; ion channels; ether a go-go; herg; proliferation; epsin; human papilloma virus; tamoxifen; patch-clamp; potassium channels; hypoxia; von Hippel-Lindau protein;
D O I：
10.1016/j.canlet.2005.02.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ion channels play important roles in health and disease. In the last few years, ail interesting relationship between potassium channels and cancer has evolved. Especially, members of the ether a go-go (EAG) potassium channels family have gained interest as research tools for detection and therapy of different cancers. This review will summarize most of the findings relating EAG channels and cancer, focusing oil mRNA expression in tissues, oncogenic properties, modulation and pharmacology. Plausible scenarios on the cellular mechanisms of EAG oncogenicity will be discussed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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页码：1 / 9
页数：9
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