Conditional alleles in mice: Practical considerations for tissue-specific knockouts

被引：110
作者：
Kwan, KM [1 ]
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA
来源：
GENESIS | 2002年 / 32卷 / 02期
关键词：
conditional genetics; Cre-IoxP; Flp-FRT; tissue-specific knockout; mosaic;
D O I：
10.1002/gene.10068
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
[No abstract available]
引用
收藏
页码：49 / 62
页数：14
相关论文
共 139 条
[51]   Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation [J].
Jackson-Grusby, L ;
Beard, C ;
Possemato, R ;
Tudor, M ;
Fambrough, D ;
Csankovszki, G ;
Dausman, T ;
Lee, P ;
Wilson, C ;
Lander, E ;
Jaenisch, R .
NATURE GENETICS, 2001, 27 (01) :31-39
[52]   Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase [J].
Jo, DW ;
Nashabi, A ;
Doxsee, C ;
Lin, Q ;
Unutmaz, D ;
Chen, J ;
Ruley, HE .
NATURE BIOTECHNOLOGY, 2001, 19 (10) :929-933
[53]   Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer [J].
Jonkers, J ;
Meuwissen, R ;
van der Gulden, H ;
Peterse, H ;
van der Valk, M ;
Berns, A .
NATURE GENETICS, 2001, 29 (04) :418-425
[54]   Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo [J].
Kaartinen, V ;
Nagy, A .
GENESIS, 2001, 31 (03) :126-129
[55]   Inducible site-specific recombination in the brain [J].
Kellendonk, C ;
Tronche, F ;
Casanova, E ;
Anlag, K ;
Opherk, C ;
Schütz, G .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (01) :175-182
[56]   Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes [J].
Kulkarni, RN ;
Brüning, JC ;
Winnay, JN ;
Postic, C ;
Magnuson, MA ;
Kahn, CR .
CELL, 1999, 96 (03) :329-339
[57]   Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease [J].
Kwon, CH ;
Zhu, XY ;
Zhang, JY ;
Knoop, LL ;
Tharp, R ;
Smeyne, RJ ;
Eberhart, CG ;
Burger, PC ;
Baker, SJ .
NATURE GENETICS, 2001, 29 (04) :404-411
[58]   Efficient in vivo manipulation of mouse genomic sequences at the zygote stage [J].
Lakso, M ;
Pichel, JG ;
Gorman, JR ;
Sauer, B ;
Okamoto, Y ;
Lee, E ;
Alt, FW ;
Westphal, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :5860-5865
[59]   TARGETED ONCOGENE ACTIVATION BY SITE-SPECIFIC RECOMBINATION IN TRANSGENIC MICE [J].
LAKSO, M ;
SAUER, B ;
MOSINGER, B ;
LEE, EJ ;
MANNING, RW ;
YU, SH ;
MULDER, KL ;
WESTPHAL, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6232-6236
[60]   Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice [J].
Larsson, NG ;
Wang, JM ;
Wilhelmsson, H ;
Oldfors, A ;
Rustin, P ;
Lewandoski, M ;
Barsh, GS ;
Clayton, DA .
NATURE GENETICS, 1998, 18 (03) :231-236
12345678910