Synthesis of Substituted 1H-Indazoles by Pyrazole Annelation to an Arene

被引：4

作者：

Garkushenko, A. K. ^{[1
]}

Sorokina, O. P. ^{[1
]}

Kryuchkova, G. A. ^{[1
]}

Zmeev, A. A. ^{[1
]}

Makarova, M. A. ^{[1
]}

Vorontsova, M. A. ^{[1
]}

Sagitullina, G. P. ^{[1
]}

机构：

[1] FM Dostoevskii Omsk State Univ, Omsk 644077, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 02期

关键词：

5-aroyl-3-aryl-1,6-dimethyl-1H-indazoles; 5-amino-1,3,6-trimethyl-1H-indazole; 3,5-bis(cyclopropylcarbonyl)-2,6-dimethyl-1,4-dihydropyridine; 3,5-bis(cyclopropylcarbonyl)-2,6-dimethylpyridine; substituted ortho-aroyl-N-methylanilines; substituted N-methyl-N-nitrosobenzenes; Hantzsch synthesis; PHARMACOLOGICAL-PROPERTIES; 3-SUBSTITUTED INDAZOLES; EFFICIENT SYNTHESIS; CHEMISTRY; BENDAZAC; RING;

D O I：

10.1007/s10593-013-1244-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 1H-indazoles have been synthesized by reductive intramolecular heterocyclization of 2,4-di-aroyl-N-nitrosomethylanilines and 2,4-diacetyl-N-nitrosomethylaniline. The N-nitrosoanilines were obtained by nitrosation of N-methyl-2,4-diaroyl- and 2,4-diacetylanilines, the products of quaternary 3,5-diaroyl- and 3,5-diacetylpyridinium salt recyclization.

引用

页码：273 / 280

页数：8

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