Predictive factors associated with change rates of LV hypertrophy and renal dysfunction in CKD patients

被引:9
作者
Okumura, Kozue [1 ]
Io, Hiroaki [1 ]
Matsumoto, Mayunni [1 ]
Seto, Takuya [1 ]
Takagi, Miyuki [1 ]
Masuda, Atsumi [1 ]
Furukawa, Masako [1 ]
Nagahama, Lili [1 ]
Omote, Keisuke [1 ]
Hisada, Atsuko [1 ]
Hamada, Chieko [1 ]
Horikoshi, Satoshi [1 ]
Tomino, Yasuhiko [1 ]
机构
[1] Juntendo Univ, Fac Med, Dept Internal Med, Div Nephrol, Tokyo 1138421, Japan
关键词
chronic kidney disease; LV hypertrophy; left ventricular mass index; pre-dialysis; LEFT-VENTRICULAR HYPERTROPHY; CHRONIC KIDNEY-DISEASE; SERUM PHOSPHATE; ECHOCARDIOGRAPHY; THERAPY; ANEMIA; RISK; MASS; ERYTHROPOIETIN; MORTALITY;
D O I
10.5414/CN107569
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background: This longitudinal study is the first report on the factors associated with change rates of the estimated glomerular filtration rate (eGFR) and left ventricular mass index (LVMI) using echocardiography in chronic kidney disease (CKD) patients. Methods: Measurements of biochemical and physical values, and LVMI evaluated by echocardiography were performed twice (baseline and follow-up period) in pre-dialysis CKD patients. Blood and urine samples were collected at the time of the echocardiographic study. Results: The change rates of hemoglobin (Hb) and transferrin saturation (TSAT: (serum iron/total iron binding capacity)) were identified as independent risk factors for changes in eGFR by multivariate regression analysis. In the LVMI improvement group, the change rate of systolic blood pressure (sBP) was identified as an independent factor for change in LVMI. In the LVMI worsening group, the change rates of sBP, proteinuria and Bib were identified as independent risk factors for changes in LVMI. Conclusions: It appears that treatment of renal and iron deficiency anemia might prevent progression of renal dysfunction. To prevent LV hypertrophy in CKD patients, renal anemia, hypertension and proteinuria should be treated.
引用
收藏
页码:7 / 14
页数:8
相关论文
共 32 条
  • [1] Association of Serum Phosphate with Vascular and Valvular Calcification in Moderate CKD
    Adeney, Kathryn L.
    Siscovick, David S.
    Ix, Joachim H.
    Seliger, Stephen L.
    Shlipak, Michael G.
    Jenny, Nancy S.
    Kestenbaum, Bryan R.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (02): : 381 - 387
  • [2] [Anonymous], 2001, Am J Kidney Dis, V37, pS182
  • [3] Association of kidney function with anemia - The Third National Health and Nutrition Examination Survey (1988-1994)
    Astor, BC
    Muntner, P
    Levin, A
    Eustace, JA
    Coresh, J
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (12) : 1401 - 1408
  • [4] MAGNETIC-RESONANCE-IMAGING COMPARED TO ECHOCARDIOGRAPHY TO ASSESS LEFT-VENTRICULAR MASS IN THE HYPERTENSIVE PATIENT
    BOTTINI, PB
    CARR, AA
    PRISANT, LM
    FLICKINGER, FW
    ALLISON, JD
    GOTTDIENER, JS
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 1995, 8 (03) : 221 - 228
  • [5] Prolonged therapy with ACE inhibitors induces a regression of left ventricular hypertrophy of dialyzed uremic patients independently from hypotensive effects
    Cannella, G
    Paoletti, E
    Delfino, R
    Peloso, G
    Rolla, D
    Molinari, S
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1997, 30 (05) : 659 - 664
  • [6] Serum phosphate is associated with left ventricular mass in patients with chronic kidney disease: a cardiac magnetic resonance study
    Chue, Colin D.
    Edwards, Nicola C.
    Moody, William E.
    Steeds, Richard P.
    Townend, Jonathan N.
    Ferro, Charles J.
    [J]. HEART, 2012, 98 (03) : 219 - 224
  • [7] ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT-VENTRICULAR HYPERTROPHY - COMPARISON TO NECROPSY FINDINGS
    DEVEREUX, RB
    ALONSO, DR
    LUTAS, EM
    GOTTLIEB, GJ
    CAMPO, E
    SACHS, I
    REICHEK, N
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1986, 57 (06) : 450 - 458
  • [8] Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Drueke, Tilman B.
    Locatelli, Francesco
    Clyne, Naomi
    Eckardt, Kai-Uwe
    Macdougall, Iain C.
    Tsakiris, Dimitrios
    Burger, Hans-Ulrich
    Scherhag, Armin
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (20) : 2071 - 2084
  • [9] K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification - Foreword
    Eknoyan, G
    Levin, NW
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (02) : S14 - S266
  • [10] Long-term evolution of cardiomyopathy in dialysis patients
    Foley, RN
    Parfrey, PS
    Kent, GM
    Harnett, JD
    Murray, DC
    Barre, PE
    [J]. KIDNEY INTERNATIONAL, 1998, 54 (05) : 1720 - 1725