Simple, Clean Preparation Method for Cross-Linked α-Cyclodextrin Nanoparticles via Inclusion Complexation

被引：16
|
作者：
Zhu, Wen [1 ]
Zhang, Ke [1 ]
Chen, Yongming [1 ]
Xi, Fu [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
来源：
LANGMUIR | 2013年 / 29卷 / 20期
基金：
中国国家自然科学基金;
关键词：
POLY(ETHYLENE GLYCOL); AGGREGATION; CARBOPLATIN; HYDROGELS;
D O I：
10.1021/la400478d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, dean method was presented in this letter to prepare cross linked alpha-cyclodextrin (alpha-CD) nanoparticles with a low dispersion. The nanoparticles were synthesized in water by cross-linking the inclusion complex of alpha-CDs and poly(ethylene glycol) (PEG). The structure of the nanoparticles was characterized by H-1 NMR, nuclear overhauser enhancement spectroscopy (NOESY), and wide-angle X-ray diffraction (XRD). Spherical morphology was observed by scanning electron microscopy (SEM) for these nanoparticles. Their average hydrodynamic radius was determined to be 67 tun by dynamic light scattering (DLS). Small guest molecules could be included in the cross linked alpha-CD nanoparticles, and anticancer drug cisplatin was used to evaluate the drug release behavior.
引用
收藏
页码：5939 / 5943
页数：5
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