Therapeutic potential of targeting the Wnt/β-catenin pathway in the treatment of pancreatic cancer

被引：38

作者：

Javadinia, Seyed Alireza ^{[1
]}

Shahidsales, Soodabeh ^{[2
]}

Fanipakdel, Azar ^{[2
]}

Joudi-Mashhad, Mona ^{[2
]}

Mehramiz, Mehrane ^{[3
]}

Talebian, Sahar ^{[2
]}

Maftouh, Mona ^{[3
]}

Mardani, Ramin ^{[3
]}

Hassanian, Seyed Mahdi ^{[3
]}

Khazaei, Majid ^{[3
]}

Ferns, Gordon A. ^{[4
]}

Avan, Amir ^{[3
,5
]}

机构：

[1] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[4] Brighton & Sussex Med Sch, Dept Med Educ, Brighton, Sussex, England

[5] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 05期

关键词：

pancreas; therapeutic target; tumors; Wnt signaling pathway; Wnt/; beta-catenin; FAMILIAL ADENOMATOUS POLYPOSIS; WNT SIGNALING PATHWAY; PLANAR CELL POLARITY; BETA-CATENIN; COLORECTAL-CANCER; STEM-CELLS; PHASE-III; GEMCITABINE; MUTATIONS; ACTIVATION;

D O I：

10.1002/jcb.27835

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Wnt/beta-catenin pathway is an important, dysregulated pathway in several tumor types, including pancreatic ductal adenocarcinoma. Although the activation of this pathway is an important component of normal development, its aberrant activation resulting from activating or inactivating mutations in the CTNNB1 gene locus, or in the negative regulators AXIN and APC involving stabilization of beta-catenin, and activation of target genes leads to a more aggressive phenotype, suggesting its potential value as a therapeutic target in the treatment of pancreatic ductal adenocarcinoma. A number of small molecule and biologic agents have now been developed for targeting this pathway. This review summarizes the current knowledge about the therapeutic potential of targeting the Wnt pathway with particular emphasis on preclinical/clinical studies in the treatment of pancreatic ductal adenocarcinoma.

引用

页码：6833 / 6840

页数：8

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