Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells

被引：39

作者：

Wang, Zhihui ^{[1
]}

Tian, Yongfeng ^{[1
]}

Zhang, Hua ^{[1
]}

Qin, Yanmei ^{[1
]}

Li, Dong ^{[1
]}

Gan, Li ^{[1
]}

Wu, Fanhong ^{[1
]}

机构：

[1] Shanghai Inst Technol, Sch Chem & Environm Engn, Dept Pharmaceut Engn, Shanghai, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2016年 / 11卷

关键词：

mesoporous silica nanoparticles; hyaluronic acid; pH-sensitive lipid membrane; CD44; receptor; HeLa cells; DRUG-DELIVERY; RELEASE; LIPOSOMES; EFFICACY; THERAPY; IMMOBILIZATION; CARRIER;

D O I：

10.2147/IJN.S117184

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study, novel hyaluronic acid-pH stimuli-responsive lipid membrane mesoporous silica nanoparticles (HA-PL-MSNs) were designed and assembled, with the chemotherapeutic agent doxorubicin (DOX) as the model drug. HA-PL-MSNs exhibited a well-defined mesostructure covered by lipid bilayer and particle size of similar to 150 nm. The drug loading capacity was up to similar to 18.2%. DOX release could be effectively retained by the lipid bilayer in pH 7.4 buffer and exhibited a pH-triggered burst release in the acidic condition. Confocal laser scanning microscopy and fluorescence-activated cell sorting showed that HA-PL-MSNs exhibited higher cellular uptake efficiency via CD44 receptor-mediated endocytosis compared with PL-MSNs in HeLa cells. In vitro cytotoxicity studies demonstrated that HA-PL-MSNs could effectively enhance the targeted delivery of DOX and restrain the growth of HeLa cells. This might provide a promising alternative for the development of a targeted anticancer drug delivery system.

引用

页码：6485 / 6497

页数：13

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