The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

被引：27

作者：

Kim, Jong-Eun ^{[1
]}

Kang, Seong-Su ^{[2
]}

Choi, Kyung-Hee ^{[3
]}

Shim, June-Sung ^{[4
]}

Jeong, Chang-Mo ^{[5
]}

Shin, Sang-Wan ^{[1
]}

Huh, Jung-Bo ^{[5
]}

机构：

[1] Korea Univ, Inst Clin Dent Res, Postgrad Sch Clin Dent, Seoul, South Korea

[2] Chonnam Natl Univ, Coll Vet Med, Kwangju, South Korea

[3] Cowellmedi Co, Inst Res & Dev, Pusan, South Korea

[4] Yonsei Univ, Coll Dent, Dept Prosthodont, Seoul 120749, South Korea

[5] Pusan Natl Univ, Sch Dent, Dept Prosthodont, Pusan 609735, South Korea

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2013年 / 115卷 / 06期

关键词：

SIZE DEFECT MODEL; MORPHOGENETIC PROTEIN-2; TITANIUM IMPLANTS; DENTAL IMPLANT; FACTOR VEGF; OSTEOBLAST DIFFERENTIATION; DUAL DELIVERY; OSSEOINTEGRATION; AUGMENTATION; ANGIOGENESIS;

D O I：

10.1016/j.oooo.2011.10.040

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objectives. The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. Study Design. Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. Results. The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P < .05). Conclusions. Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.

引用

页码：E24 / E31

页数：8

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