Targeting FOXM1 in cancer

被引：157

作者：

Halasi, Marianna ^{[1
]}

Gartel, Andrei L. ^{[1
]}

机构：

[1] Univ Illinois, Dept Med, Chicago, IL 60612 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2013年 / 85卷 / 05期

关键词：

FOXM1; RNAi; Proteasome inhibitors; NPM; ARF; Apoptosis; FORKHEAD BOX M1; TRANSCRIPTION FACTOR FOXM1; SQUAMOUS-CELL CARCINOMA; FACTOR-KAPPA-B; PROTEASOME INHIBITORS; DOWN-REGULATION; GROWTH-INHIBITION; SIGNALING PATHWAY; DOWNSTREAM TARGET; INDUCED APOPTOSIS;

D O I：

10.1016/j.bcp.2012.10.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oncogenic transcription factor FOXM1 is overexpressed in the majority of human cancers. In addition, FOXM1 has been implicated in cell migration, invasion, angiogenesis and metastasis. The important role of FOXM1 in cancer affirms its significance for therapeutic intervention. Current data suggest that targeting FOXM1 in mono- or combination therapy may have promising therapeutic benefits for the treatment of cancer. However, challenges with the delivery of anti-FOXM1 siRNA to tumors and the absence of small molecules, which specifically inhibit FOXM1, are delaying the development of FOXM1 inhibitors as feasible anticancer drugs. In this review, we describe and summarize the efforts that have been made to target FOXM1 in cancer and the consequences of FOXM1 suppression in human cancer cells. (C)2012 Elsevier Inc. All rights reserved.

引用

页码：644 / 652

页数：9

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