Risk Factors for Early Death in Transient Myeloproliferative Disorder Without Phenotypic Features of Down Syndrome A Case Report and Literature Review

被引：3

作者：

Kawase, Koya ^{[1
]}

Azuma, Eiichi ^{[2
]}

Ohshita, Hironori ^{[1
]}

Tanaka, Tatsushi ^{[1
]}

Hanada, Yu ^{[1
]}

Sasaki, Tomoaki ^{[1
]}

Sugimoto, Mari ^{[1
]}

Togawa, Takao ^{[1
]}

Kouwaki, Masanori ^{[1
]}

Ito, Tsuyoshi ^{[1
]}

Hirayama, Masahiro ^{[2
]}

Koyama, Norihisa ^{[1
]}

机构：

[1] Toyohashi Municipal Hosp, Dept Pediat, Toyohashi, Aichi 4418570, Japan

[2] Mie Univ, Grad Sch Med, Dept Pediat & Cell Transplantat, Tsu, Mie, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2012年 / 34卷 / 06期

关键词：

transient myeloproliferative disorder; risk factor; mosaic; hepatic fibrosis; ACUTE MEGAKARYOBLASTIC LEUKEMIA; ABNORMAL MYELOPOIESIS; NORMAL INFANT; MOSAIC TRISOMY-21; NORMAL NEWBORN; GATA1; MUTATION; BLAST CELLS; PROLIFERATION; NEONATE; CHILD;

D O I：

10.1097/MPH.0b013e318249597f

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Not only in newborns with Down syndrome, but newborns without phenotypic features of Down syndrome also develop transient myeloproliferative disorder (TMD). In these cases, trisomy 21 and related chromosomal abnormalities are either constitutionally mosaic or limited to blood cells. Risk factors for early death of these patients are unknown so far. We here report a fatal case of TMD without phenotypic features of Down syndrome and review literature to identify risk factors associated with early death. Not only are gestational age and white blood cell count risk factors for early death in TMD with Down syndrome, but they also appear to be risk factors in TMD without Down syndrome.

引用

页码：475 / 479

页数：5

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