Association of the rs9939609 gene variant in FTO with insulin resistance, cardiovascular risk factor and serum adipokine levels in obese patients

Introduction: The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels. Material and methods: A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (NOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured. Results: Insulin (122.2 +/- 101.8 pmol/L vs. 104.5 +/- 61.5 pmol/L vs. 112.1 +/- 74.3 pmol/L: p < 0.05) and HOMA-IR values (4.76 +/- 4.4 vs. 3.71 +/- 2.5 vs. 3.76 +/- 3.1; p < 0.05) were higher in TT group than AT and AA groups. Triglycerides values were higher in TT group than AA group (1.42 +/- 0.71 mmol/L vs. 1.39 +/- 0.69 mmol/L vs. 1.23 +/- 0.64 mmol/L; p < 0.05). Adiponectin levels were lower in TT genotype group than AA genotype group (35801.2 +/- 35,912.3 ng/L vs. 26,718.1 +/- 36,323.1 ng/L vs. 21,112.3 +/- 25,623.1 ng/L p < 0.05). Conclusion: The FTO gene polymorphism, rs9939609, was found to be associated with insulin resistance, insulin, triglyceride and adiponectin levels in obese patients with 7 variant.