Horner-Wadsworth-Emmons Reactions in THF: Effect of Hydroperoxide Species

被引：2

作者：

Jarvis, Amanda G. ^{[1
]}

Wells, Elizabeth R. ^{[1
]}

Fairlamb, Ian J. S. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

SYNLETT | 2013年 / 24卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

alkenes; phosphorus; peroxides; furan; reduction; ALPHA; ACTIVATION; CLEAVAGE;

D O I：

10.1055/s-0033-1339200

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Horner-Wadsworth-Emmons (HWE) reactions routinely employ tetrahydrofuran (THF) as the reaction solvent. In this paper we show that THF adducts (derived from THF-hydroperoxide species) of HWE phosphonate ester compounds are formed under microwave irradiation (i.e., under pressure), or in the presence of a reductant [e.g., P(OEt)(3)] in a conventionally heated reaction.

引用

页码：1493 / 1496

页数：4

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