A review of therapeutic agents for the management of pulmonary arterial hypertension

被引：10

作者：

Hahn, Stella S. ^{[1
]}

Makaryus, Mina ^{[1
]}

Talwar, Arunabh ^{[1
]}

Narasimhan, Mangala ^{[1
]}

Zaidi, Gulrukh ^{[1
]}

机构：

[1] Northwell Hlth, Div Pulm Crit Care & Sleep Med, 410 Lakeville Rd,Suite 107, New Hyde Pk, NY 11042 USA

来源：

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE | 2017年 / 11卷 / 01期

关键词：

pulmonary arterial hypertension; prostanoid; endothelin receptor antagonist; phosphodiesterase inhibitor; soluble guanylate cyclase stimulator; ENDOTHELIN RECEPTOR ANTAGONIST; RANDOMIZED CONTROLLED-TRIAL; CONTINUOUS INTRAVENOUS EPOPROSTENOL; NITRIC-OXIDE SYNTHASE; 5 INHIBITOR THERAPY; DOUBLE-BLIND; INHALED ILOPROST; ORAL TREPROSTINIL; COMBINATION THERAPY; PROSTACYCLIN ANALOG;

D O I：

10.1177/1753465816665289

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understanding of the pathobiology of PAH and its natural history has led to the development of numerous targeted therapies. Despite these advances there is significant progression of disease and the survival rate remains low. This article reviews the agents currently available for the medical management of PAH.

引用

收藏

页码：46 / 63

页数：18

相关论文

共 50 条

[31] Risk stratification and medical therapy of pulmonary arterial hypertension [J].

Galie, Nazzareno ;

Channick, Richard N. ;

Frantz, Robert P. ;

Gruenig, Ekkehard ;

Jing, Zhi Cheng ;

Moiseeva, Olga ;

Preston, Ioana R. ;

Pulido, Tomas ;

Safdar, Zeenat ;

Tamura, Yuichi ;

McLaughlin, Vallerie V. .

EUROPEAN RESPIRATORY JOURNAL, 2019, 53 (01)

[32] Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension [J].

Jain, Snigdha ;

Khera, Rohan ;

Girotra, Saket ;

Badesch, David ;

Wang, Zhen ;

Murad, Mohammad Hassan ;

Blevins, Amy ;

Schmidt, Gregory A. ;

Singh, Siddharth ;

Gerke, Alicia K. .

CHEST, 2017, 151 (01) :90-105

[33] A Bayesian network meta-analysis on the efficacy and safety of eighteen targeted drugs or drug combinations for pulmonary arterial hypertension [J].

Wang, Sumei ;

Yu, Miao ;

Zheng, Xiangchun ;

Dong, Shangjuan .

DRUG DELIVERY, 2018, 25 (01) :1898-1909

[34] Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension [J].

Idrees, Majdy M. ;

Swiston, John ;

Nizami, Imran ;

Al Dalaan, Abdullah ;

Levy, Robert D. .

ANNALS OF THORACIC MEDICINE, 2014, 9 (05) :79-91

[35] Pulmonary Arterial Hypertension: A Review in Pharmacotherapy [J].

Patel, Bhaumik B. ;

Feng, Ying ;

Cheng-Lai, Angela .

CARDIOLOGY IN REVIEW, 2015, 23 (01) :33-51

[36] Selexipag, a selective prostacyclin receptor agonist in pulmonary arterial hypertension: a pharmacology review [J].

Honorato Perez, Jesus .

EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2017, 10 (07) :753-762

[37] A Contemporary Approach to Pulmonary Arterial Hypertension [J].

Krishnan, Udhay ;

Horn, Evelyn M. .

CURRENT ATHEROSCLEROSIS REPORTS, 2016, 18 (09)

[38] Pharmacologic Treatment of Pulmonary Arterial Hypertension [J].

Ramani, Gautam V. ;

Gill, Sartraj .

CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (22) :3963-3973

[39] Medical Treatment of Pulmonary Arterial Hypertension [J].

Sahay, Sandeep ;

Humbert, Marc ;

Sitbon, Olivier .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 38 (05) :686-700

[40] Recent advances and future perspectives in therapeutic strategies for pulmonary arterial hypertension [J].

Yao, Atsushi .

JOURNAL OF CARDIOLOGY, 2012, 60 (5-6) :344-349

← 1 2 3 4 5 →