N-tert-butoxycarbonyl-N,N′-ethylene-bridged (S)-tyrosyl-(S)-tyrosine methyl ester

被引:1
|
作者
Yamato, K [1 ]
Miyake, H [1 ]
Hirotsu, K [1 ]
Kojima, Y [1 ]
机构
[1] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 558585, Japan
关键词
D O I
10.1107/S0108270199002449
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The title compound, a pseudopeptide, methyl (2S)-3-(4-hydroxyphenyl)-2-[(3S)-4-(tert-butoxycarbonyl)-3-(4-hydroxybenzyl)-2-oxopiperazin-1-yl]propionate, C26H32N2O7, was crystallized from an H2O/methanol solution. The two N-substituted chains on the piperazin-2-one (MKP) ring lie in the quasi-equatorial position and the third chain lies in the quasi-axial position. Each side chain on the tyrosines is located opposite the MKP ring. The MKP ring has a pseudo-chair form.
引用
收藏
页码:1023 / 1025
页数:3
相关论文
共 50 条
  • [41] 2(S)-N-tert-butoxycarbonylamino-N-methoxy-N-methylbutanamide
    Sawatzki, P
    Mikeska, T
    Nieger, M
    Hupfer, H
    Kolter, T
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2002, 58 : O1415 - O1417
  • [42] A facile method for the transformation of N-(tert-butoxycarbonyl) α-amino acids to N-unprotected α-amino methyl esters
    Chen, BC
    Skoumbourdis, AP
    Guo, P
    Bednarz, MS
    Kocy, OR
    Sundeen, JE
    Vite, GD
    JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (25): : 9294 - 9296
  • [43] Synthesis of isotopomers of N-(tert-butoxycarbonyl)-4-cyano-L-phenylalanine methyl ester: choice of cyanation solvent
    Bazewicz, Christopher G.
    Lipkin, Jacob S.
    Lozinak, Kristen A.
    Watson, Matthew D.
    Brewer, Scott H.
    TETRAHEDRON LETTERS, 2011, 52 (51) : 6865 - 6868
  • [44] Asymmetric Synthesis of Methyl N-(tert-Butoxycarbonyl)indoline-2-carboxylates
    Zhang, Qianqian
    Ding, Qunshan
    Song, Chuanjun
    Chang, Junbiao
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (01) : 221 - 227
  • [45] ENHANCEMENT BY TYROSINE METHYL-ESTER OF GASTRIC CARCINOGENESIS INDUCED BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE IN WISTAR RATS
    TATSUTA, M
    IISHI, H
    BABA, M
    TANIGUCHI, H
    INTERNATIONAL JOURNAL OF CANCER, 1991, 48 (05) : 785 - 788
  • [46] Syntheses of silver(I) complexes with N,N'-ethylene-bridged-(S)-histidyl-(S)-histidine and -(S)-methionyl-(S)-methionine derivatives
    Kojima, Y
    Watanabe, M
    Miyake, H
    CHEMISTRY LETTERS, 1995, (12) : 1097 - 1098
  • [47] Chemical and enzymatic resolution of (R,S)-N-(tert-butoxycarbonyl)-3-hydroxymethylpiperidine
    Goswami, A
    Howell, JM
    Hua, EY
    Mirfakhrae, KD
    Soumeillant, MC
    Swaminathan, S
    Qian, XH
    Quiroz, FA
    Vu, TC
    Wang, XB
    Zheng, B
    Kronenthal, DR
    Patel, RN
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2001, 5 (04) : 415 - 420
  • [48] N-(2-hydroxynaphthylmethyl)-(S)-proline methyl ester
    Zheng, PW
    Li, CB
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2003, 59 : O1621 - O1623
  • [49] Methyl N-(tert-Butoxycarbonyl)glycyl-L-valyl-L-tryptophanate
    Banumathi, Sankaran
    Velmurugan, Devadasan
    Subramanian, Easwara
    Katti, Sethuram Bandacharya
    Haq, Wahajul
    Acta Crystallographica, Section C: Crystal Structure Communications, 1998, 54 (pt 11): : 1681 - 1683
  • [50] Methyl N-(tert-butoxycarbonyl)glycyl-L-valyl-L-tryptophanate
    Banumathi, S
    Velmurugan, D
    Subramanian, E
    Katti, SB
    Haq, W
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1998, 54 : 1681 - 1683