Adoptive transfer of allogeneic antigen-specific T cells

被引：36

作者：

Riddell, SR ^{[1
]}

Bleakley, M ^{[1
]}

Nishida, T ^{[1
]}

Berger, C ^{[1
]}

Warren, EH ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2006年 / 12卷 / 01期

关键词：

adoptive transfer; T-cell response;

D O I：

10.1016/j.bbmt.2005.10.025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect. (C) 2006 American Society for Blood and Marrow Transplantation.

引用

收藏

页码：9 / 12

页数：4

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