Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation

被引:84
作者
Jackson-Jones, Lucy H. [1 ,2 ]
Duncan, Sheelagh M. [1 ]
Magalhaes, Marlene S. [2 ]
Campbell, Sharon M. [1 ]
Maizels, Rick M. [1 ]
McSorley, Henry J. [1 ,3 ]
Allen, Judith E. [1 ,4 ]
Benezech, Cecile [2 ]
机构
[1] Univ Edinburgh, Inst Immunol & Infect Res, Edinburgh EH9 3FL, Midlothian, Scotland
[2] Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland
[3] Univ Edinburgh, Ctr Inflammat Res, Edinburgh EH16 4TJ, Midlothian, Scotland
[4] Univ Manchester, Fac Biol Med & Hlth, AV Hill Bldg, Manchester M13 9PT, Lancs, England
来源
NATURE COMMUNICATIONS | 2016年 / 7卷
基金
英国医学研究理事会;
关键词
VACCINE-INDUCED PROTECTION; ANTIBODY-PRODUCING CELLS; B-CELLS; MILKY SPOTS; LITOMOSOIDES-SIGMODONTIS; FILARIAL INFECTION; MEDIATE INNATE; B-1; CELLS; MICE; IMMUNITY;
D O I
10.1038/ncomms12651
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Fat-associated lymphoid clusters (FALC) are inducible structures that support rapid innate-like B-cell immune responses in the serous cavities. Little is known about the physiological cues that activate FALCs in the pleural cavity and more generally the mechanisms controlling B-cell activation in FALCs. Here we show, using separate models of pleural nematode infection with Litomosoides sigmodontis and Altenaria alternata induced acute lung inflammation, that inflammation of the pleural cavity rapidly activates mediastinal and pericardial FALCs. IL-33 produced by FALC stroma is crucial for pleural B1-cell activation and local IgM secretion. However, B1 cells are not the direct target of IL-33, which instead requires IL-5 for activation. Moreover, lung inflammation leads to increased IL-5 production by type 2 cytokine-producing innate lymphoid cells (ILC2) in the FALC. These findings reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
引用
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页数:14
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