Biological principles of microRNA-mediated regulation: shared themes amid diversity

被引：656

作者：

Flynt, Alex S. ^{[1
]}

Lai, Eric C. ^{[1
]}

机构：

[1] Sloan Kettering Inst, Dept Dev Biol, New York, NY 10065 USA

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg2455

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression. Such themes may reflect some of the inherent advantages of exploiting microRNA control in biological circuits, and provide insight into the consequences of microRNA dysfunction in disease.

引用

页码：831 / 842

页数：12

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