Iridium-Catalyzed Enantioselective Hydroarylation of Alkenes through C-H bond Activation: Experiment and Computation

被引：25

作者：

Shinde, Valmik S. ^{[1
]}

Mane, Manoj V. ^{[1
]}

Cavallo, Luigi ^{[1
]}

Rueping, Magnus ^{[1
]}

机构：

[1] King Abdullah Univ Sci & Technol, KAUST Catalysis Ctr, Thuwal 239556900, Saudi Arabia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 37期

关键词：

asymmetric catalysis; C-H activation; hydroarylation; iridium; quniox P*; PINACOL MACROCYCLIZATION CASCADE; AROMATIC IMINES; INTRAMOLECULAR HYDROARYLATION; COUPLING REACTIONS; HYDROGEN-BONDS; DIAZONAMIDE-A; CYCLIZATION; CONSTRUCTION; FUNCTIONALIZATION; ALKYLATION;

D O I：

10.1002/chem.202001793

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new catalytic enantioselective hydroarylation of unactivated olefins is developed that provides rapid access to functionalized chiral dihydrobenzofurans with good yields and excellent enantioselectivities. Simple aromatic ketones or amides act as a directing group allowing the regioselective reaction at the more hinderedorthoposition. Tertiary benzylic stereocenters are obtained directly under mild reaction conditions and with complete atom economy from readily available starting materials.

引用

页码：8308 / 8313

页数：6

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