Involvement of FoxM1 in Non-Small Cell Lung Cancer Recurrence

被引：20
作者：
Xu, Nuo [3 ]
Wu, Sheng-Di [2 ]
Wang, Hao [1 ]
Wang, Qun [1 ]
Bai, Chun-Xue [3 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Dept Thoracol, Shanghai 200433, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol & Hepatol, Shanghai 200433, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Pulm Med, Shanghai 200433, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 09期
关键词：
Lung cancer; non-small cell lung cancer; FoxM1; recurrence; predictive factor; STAGE; EXPRESSION; RESISTANCE; ADENOCARCINOMA; RADIOTHERAPY; GEFITINIB; CISPLATIN; INVASION; GROWTH; TUMORS;
D O I：
10.7314/APJCP.2012.13.9.4739
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Predictive biomarkers for lung cancer recurrence after curative tumor resection remain unclear. This study set out to assess the role of FoxM1 in the recurrence of non-small cell lung cancer. Methods: Immunohistochemistry for FoxM1 expression was performed on paraffin-embedded tumor tissues from 165 NSCLC patients. Association of FoxM1 expression with clinicopathological parameters and disease free survival were evaluated. Results: Our results indicated FoxM1 expression to be significantly associated with poorer tissue differentiation (P = 0.03), higher TNM stage (P < 0.01), lymph node metastasis (P < 0.01), advanced tumor stage (P < 0.01), and poorer disease free survival (P < 0.01). Multivariable analysis showed that FoxM1 expression increased the hazard of recurrence (hazard ratio=1.96, 95% CI, 1.04-3.17, P < 0.05), indicating that FoxM1 is an independent and significant predictor of lung cancer recurrence. Conclusion: Therefore, FoxM1 is an independent risk factor for recurrence of NSCLC. Elevated FoxM1 expression could be used as an indicator of poor disease free survival.
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收藏
页码：4739 / 4743
页数：5
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