Determination of CMPO using HPLC-UV

被引：12

作者：

Elias, Gracy ^{[1
]}

Groenewold, Gary S. ^{[2
]}

Mincher, Bruce J. ^{[3
]}

Mezyk, Stephen P. ^{[4
]}

机构：

[1] Idaho Natl Lab, Chem & Radiat Measurement Dept, Idaho Falls, ID 83415 USA

[2] Idaho Natl Lab, Interfacial Chem Dept, Idaho Falls, ID 83415 USA

[3] Idaho Natl Lab, Aqueous Separat & Radiochem Dept, Idaho Falls, ID 83415 USA

[4] Calif State Univ Long Beach, Dept Chem & Biochem, Long Beach, CA 90840 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2012年 / 1243卷

关键词：

CMPO; Radiolysis; High performance liquid chromatography; Electrospray ionization mass spectrometry; Ligands; Radionuclides; TRIVALENT F-ELEMENTS; NITRIC-ACID MEDIA; OCTYL(PHENYL)-N; N-DIISOBUTYLCARBAMOYLMETHYLPHOSPHINE OXIDE; SUBSTITUTED MALONAMIDES; EXTRACTION BEHAVIOR; SOLVENT-EXTRACTION; FISSION-PRODUCTS; ACTINIDES; AM(III); COMPLEXES;

D O I：

10.1016/j.chroma.2012.04.047

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide (CMPO) is an extractant proposed for selective separation of radionuclide metals from used nuclear fuel solutions using solvent extraction. Radiolysis reactions can degrade CMPO and reduce separation performance and hence methods for measuring the concentration of CMPO are needed. A novel high performance liquid chromatography (HPLC) method was developed for measuring CMPO in dodecane that featured a low pH buffer, octanol as a co-solvent with 2-propanol, and ultraviolet (UV) detection. Validation data indicated that the HPLC-UV method for CMPO determination provided good linearity, sensitivity, accuracy and precision. Method performance was evaluated using CM PO samples that had undergone radiolysis, and the results showed a decrease in CMPO concentration and the appearance of degradation products. The degradation products were identified using electrospray ionization mass spectrometry, which also showed formation of CMPO-nitric acid complexes that account for the apparent loss of CMPO in an acidic environment, independent of irradiation. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：47 / 52

页数：6

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