Solid phase heterocyclic chemistry

A review is given of the methods for the traceless solid-phase synthesis of various heterocyclic compounds, whereby the presence of obvious traces of linkage to the solid support are eliminated. These approaches are organized into several distinct categories as follows: i) use of C-H linkers results in formation of a C-H bond in the seceding molecule during the cleavage step, ii) use of N-H linkers results in formation of an N-H bond in seceding molecule, iii) application of a cyclative cleavage strategy yields a newly formed C-N bond, and iiii) inducement of modifications to the target molecule during or after the cleavage step obscures or obliterates the previous point of attachment to the solid support.