Homeostasis and function of regulatory T cells in aging

被引：128

作者：

Raynor, Jana

Lages, Celine S.

Shehata, Hesham

Hildeman, David A. ^{[1
]}

Chougnet, Claire A.

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Cellular & Mol Immunol, Dept Pediat, Cincinnati, OH 45229 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 04期

关键词：

AGED MICE; BINDING CYTOKINES; INFECTION; EFFECTOR; INTERLEUKIN-2; EXPRESSION; NAIVE; IL-2; IMMUNOSENESCENCE; REACTIVATION;

D O I：

10.1016/j.coi.2012.04.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A hallmark of aging is the progressive deterioration of immune function. Age-related immune suppression increases susceptibility to infectious diseases and cancer, significant causes of morbidity and mortality in the elderly. In particular, age-related T cell dysfunction is a major contributor to 'immune-senescence'. Recently, it has become clear that the frequency of regulatory T cells (Treg) significantly increases in aged mice and humans. As Treg control the intensity of T cell responses, their accrual probably contributes to age-related immune dysfunction. This review will focus on mechanisms underlying Treg homeostasis and function in aging.

引用

收藏

页码：482 / 487

页数：6

相关论文

共 51 条

[31] Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim [J].

Paschos, Kostas ;

Smith, Paul ;

Anderton, Emma ;

Middeldorp, Jaap M. ;

White, Robert E. ;

Allday, Martin J. .

PLOS PATHOGENS, 2009, 5 (06)

[32] Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens [J].

Punkosdy, George A. ;

Blain, Melissa ;

Glass, Deborah D. ;

Lozano, Mary M. ;

O'Mara, Leigh ;

Dudley, Jaquelin P. ;

Ahmed, Rafi ;

Shevach, Ethan M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (09) :3677-3682

[33] Higher frequency of regulatory T suppressive activity cells in the elderly and increased in neurodegeneration [J].

Rosenkranz, Daniela ;

Weyer, Sascha ;

Tolosa, Eva ;

Gaenslen, Alexandra ;

Berg, Daniela ;

Leyhe, Thomas ;

Gasser, Thomas ;

Stoltze, Lars .

JOURNAL OF NEUROIMMUNOLOGY, 2007, 188 (1-2) :117-127

[34] FOXP3+ regulatory T cells in the human immune system [J].

Sakaguchi, Shimon ;

Miyara, Makoto ;

Costantino, Cristina M. ;

Hafler, David A. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (07) :490-500

[35] Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype [J].

Santner-Nanan, Brigitte ;

Seddiki, Nabila ;

Zhu, Erhua ;

Quent, Verena ;

Kelleher, Anthony ;

Fazekas de St Groth, Barbara ;

Nanan, Ralph .

INTERNATIONAL IMMUNOLOGY, 2008, 20 (03) :375-383

[36] Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease [J].

Sather, Blythe D. ;

Treuting, Piper ;

Perdue, Nikole ;

Miazgowicz, Mike ;

Fontenot, Jason D. ;

Rudensky, Alexander Y. ;

Campbell, Daniel J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (06) :1335-1347

[37] High accumulation of T regulatory cells prevents the activation of immune responses in aged animals [J].

Sharma, Sanjay ;

Dominguez, Ana Lucia ;

Lustgarten, Joseph .

JOURNAL OF IMMUNOLOGY, 2006, 177 (12) :8348-8355

[38] Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors [J].

Shinjyo, T ;

Kuribara, R ;

Inukai, T ;

Hosoi, H ;

Kinoshita, T ;

Miyajima, A ;

Houghton, PJ ;

Look, AT ;

Ozawa, K ;

Inaba, T .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (03) :854-864

[39]

Taams LS, 2002, EUR J IMMUNOL, V32, P1621, DOI 10.1002/1521-4141(200206)32:6<1621::AID-IMMU1621>3.0.CO

[40]

2-Q

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