Homeostasis and function of regulatory T cells in aging

被引：128
作者：
Raynor, Jana
Lages, Celine S.
Shehata, Hesham
Hildeman, David A. [1 ]
Chougnet, Claire A.
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Div Cellular & Mol Immunol, Dept Pediat, Cincinnati, OH 45229 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 04期
关键词：
AGED MICE; BINDING CYTOKINES; INFECTION; EFFECTOR; INTERLEUKIN-2; EXPRESSION; NAIVE; IL-2; IMMUNOSENESCENCE; REACTIVATION;
D O I：
10.1016/j.coi.2012.04.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A hallmark of aging is the progressive deterioration of immune function. Age-related immune suppression increases susceptibility to infectious diseases and cancer, significant causes of morbidity and mortality in the elderly. In particular, age-related T cell dysfunction is a major contributor to 'immune-senescence'. Recently, it has become clear that the frequency of regulatory T cells (Treg) significantly increases in aged mice and humans. As Treg control the intensity of T cell responses, their accrual probably contributes to age-related immune dysfunction. This review will focus on mechanisms underlying Treg homeostasis and function in aging.
引用
收藏
页码：482 / 487
页数：6
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