A hallmark of aging is the progressive deterioration of immune function. Age-related immune suppression increases susceptibility to infectious diseases and cancer, significant causes of morbidity and mortality in the elderly. In particular, age-related T cell dysfunction is a major contributor to 'immune-senescence'. Recently, it has become clear that the frequency of regulatory T cells (Treg) significantly increases in aged mice and humans. As Treg control the intensity of T cell responses, their accrual probably contributes to age-related immune dysfunction. This review will focus on mechanisms underlying Treg homeostasis and function in aging.
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UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Agius, Elaine
;
Lacy, Katie E.
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UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Lacy, Katie E.
;
Vukmanovic-Stejic, Milica
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UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Vukmanovic-Stejic, Milica
;
Jagger, Ann L.
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Kings Coll London, Dept Immunobiol, Div Immunol Infect & Inflammatory Dis, Sch Med Guys, London SE1 9RT, England
St Thomas Hosp, London SE1 9RT, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Jagger, Ann L.
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Papageorgiou, Anna-Pia
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UCL, Dept Cell Biol, Inst Ophthalmol, London EC1V 9EL, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Papageorgiou, Anna-Pia
;
Hall, Sue
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UCL, Infect Dis & Microbiol Unit, Inst Child Hlth, London WC1N 1EH, England
UCL, Div Infect & Immun, London WC1N 1EH, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Hall, Sue
;
Reed, John R.
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h-index: 0
机构:
UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Reed, John R.
;
Curnow, S. John
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Univ Birmingham, Ctr Immune Regulat, Div Immun & Infect, MRC,Inst Biomed Res, Edgbaston B15 2TT, W Midlands, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Curnow, S. John
;
Fuentes-Duculan, Judilyn
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Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USAUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Fuentes-Duculan, Judilyn
;
Buckley, Christopher D.
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Univ Birmingham, Ctr Immune Regulat, Div Immun & Infect, MRC,Inst Biomed Res, Edgbaston B15 2TT, W Midlands, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Buckley, Christopher D.
;
Salmon, Mike
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Univ Birmingham, Ctr Immune Regulat, Div Immun & Infect, MRC,Inst Biomed Res, Edgbaston B15 2TT, W Midlands, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Salmon, Mike
;
Taams, Leonie S.
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h-index: 0
机构:
Kings Coll London, Dept Immunobiol, Div Immunol Infect & Inflammatory Dis, Sch Med Guys, London SE1 9RT, England
St Thomas Hosp, London SE1 9RT, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Taams, Leonie S.
;
Krueger, James
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Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USAUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Krueger, James
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Greenwood, John
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UCL, Dept Cell Biol, Inst Ophthalmol, London EC1V 9EL, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Greenwood, John
;
Klein, Nigel
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UCL, Infect Dis & Microbiol Unit, Inst Child Hlth, London WC1N 1EH, England
UCL, Div Infect & Immun, London WC1N 1EH, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Klein, Nigel
;
Rustin, Malcolm H. A.
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Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Rustin, Malcolm H. A.
;
Akbar, Arne N.
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UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
机构:
UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Agius, Elaine
;
Lacy, Katie E.
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h-index: 0
机构:
UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Lacy, Katie E.
;
Vukmanovic-Stejic, Milica
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h-index: 0
机构:
UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Vukmanovic-Stejic, Milica
;
Jagger, Ann L.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Dept Immunobiol, Div Immunol Infect & Inflammatory Dis, Sch Med Guys, London SE1 9RT, England
St Thomas Hosp, London SE1 9RT, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Jagger, Ann L.
;
Papageorgiou, Anna-Pia
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h-index: 0
机构:
UCL, Dept Cell Biol, Inst Ophthalmol, London EC1V 9EL, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Papageorgiou, Anna-Pia
;
Hall, Sue
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h-index: 0
机构:
UCL, Infect Dis & Microbiol Unit, Inst Child Hlth, London WC1N 1EH, England
UCL, Div Infect & Immun, London WC1N 1EH, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Hall, Sue
;
Reed, John R.
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h-index: 0
机构:
UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Reed, John R.
;
Curnow, S. John
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h-index: 0
机构:
Univ Birmingham, Ctr Immune Regulat, Div Immun & Infect, MRC,Inst Biomed Res, Edgbaston B15 2TT, W Midlands, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Curnow, S. John
;
Fuentes-Duculan, Judilyn
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h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USAUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Fuentes-Duculan, Judilyn
;
Buckley, Christopher D.
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h-index: 0
机构:
Univ Birmingham, Ctr Immune Regulat, Div Immun & Infect, MRC,Inst Biomed Res, Edgbaston B15 2TT, W Midlands, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Buckley, Christopher D.
;
Salmon, Mike
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h-index: 0
机构:
Univ Birmingham, Ctr Immune Regulat, Div Immun & Infect, MRC,Inst Biomed Res, Edgbaston B15 2TT, W Midlands, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Salmon, Mike
;
Taams, Leonie S.
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h-index: 0
机构:
Kings Coll London, Dept Immunobiol, Div Immunol Infect & Inflammatory Dis, Sch Med Guys, London SE1 9RT, England
St Thomas Hosp, London SE1 9RT, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Taams, Leonie S.
;
Krueger, James
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h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USAUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Krueger, James
;
Greenwood, John
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h-index: 0
机构:
UCL, Dept Cell Biol, Inst Ophthalmol, London EC1V 9EL, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Greenwood, John
;
Klein, Nigel
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h-index: 0
机构:
UCL, Infect Dis & Microbiol Unit, Inst Child Hlth, London WC1N 1EH, England
UCL, Div Infect & Immun, London WC1N 1EH, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Klein, Nigel
;
Rustin, Malcolm H. A.
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h-index: 0
机构:
Royal Free Hosp, Dept Dermatol, London NW3 2QG, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England
Rustin, Malcolm H. A.
;
Akbar, Arne N.
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h-index: 0
机构:
UCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, EnglandUCL, Dept Immunol, Div Infect & Immun, London W1T 4JF, England