4-hydroxy-2-quinolones 141.: Synthesis and structure of 5R-3-hydroxy-1,5-dihydropyrazolo[4,3-c]quinolin-4-ones

被引：5

作者：

Ukrainets, I. V. ^{[1
]}

Kravtsova, V. V. ^{[1
]}

Tkach, A. A. ^{[1
]}

Sim, G. ^{[2
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

[2] Far Eastern State Med Univ, Khabarovsk 680000, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2008年 / 44卷 / 02期

关键词：

1,5-dihydropyrazolo[4,3-c]quinolin-4-ones; 4-chloro-2-oxo-1,2-dihydroquinolines; p-toluene-sulfonylhydrazide; X-ray structural analysis;

D O I：

10.1007/s10593-008-0032-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 1R-4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with p-toluenesulfonylhydrazide in refluxing ethanol and in the presence of triethylamine gives the 3-hydroxy-5R-1,5-dihydropyrazolo[4,3-c]quinolin-4-ones. The possible mechanism of formation, features of the steric structure of the synthesized compounds, and their NMR and mass spectra are discussed.

引用

页码：173 / 177

页数：5

共 11 条

[1]

BARTON DHR, 1982, COMPREHENSIVE ORGANI, V2, P717

[2] On triazoles.: XL -: Non catalytic dehalogenation of some 5-chloro-1,2,4-triazolo[1,5-a]pyrimidine derivatives [J].

Berecz, G ;

Reiter, J ;

Császár, J .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1999, 36 (05) :1199-1212

[3]

BEZUGLY PA, 2003, FARMAKOM, P23

[4]

Burgi H-B, 1994, STRUCTURE CORRELATIO, V2, P741, DOI [DOI 10.1002/9783527616091, 10.1002/9783527616091]

[5]

FIESER LF, 1970, REAGENTS ORGANIC SYN, V3, P359

[6]

SHELDRICK GM, 1998, SHELXTL PLUS PC VERS

[7] 4-hydroxy-2-quinolones - 140. Synthesis and diuretic activity of arylalkylamides of 4-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid [J].

Ukrainets, I. V. ;

Bereznyakova, N. L. ;

Parshikov, V. A. ;

Kravchenko, V. N. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2008, 44 (01) :64-72

[8]

Ukrainets I. V., 2006, CHEM HETEROCYCL COMP, V42, P475

[9]

Ukrainets I. V., 2006, CHEM HETEROCYCL COMP, V42, P343

[10]

Ukrainets I. V., 2007, CHEM HETEROCYCL COMP, V43, P1525

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