Haematogenous cytokeratin 20 mRNA as a predictive marker for recurrence in oral cancer patients

被引：34

作者：

Kawamata, H ^{[1
]}

Uchida, D ^{[1
]}

Nakashiro, K ^{[1
]}

Hino, S ^{[1
]}

Omotehara, F ^{[1
]}

Yoshida, H ^{[1
]}

Sato, R ^{[1
]}

机构：

[1] Univ Tokushima, Sch Dent, Dept Oral & Maxillofacial Surg 2, Tokushima 770, Japan

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 80卷 / 3-4期

关键词：

oral cancer; CK20; recurrence; metastasis;

D O I：

10.1038/sj.bjc.6690377

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the expression of cytokeratin 20 (CK20) mRNA in the peripheral blood of oral squamous cell carcinoma (SCC) patients by reverse transcriptase polymerase chain reaction (RT-PCR). Eleven out of 12 oral SCC patients showed positive RT-PCR results. However, there is no clear relationship between the haematogenous CK20 mRNA and the metastasis. After initial treatment, all of the tumour-free survivors tested showed negative RT-PCR results. CK20 mRNA in peripheral blood can be used as a marker for tumour recurrence but not for metastasis in oral SCC patients.

引用

页码：448 / 452

页数：5

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