CHEMICAL BIOLOGY Greasy tags for protein removal

被引：71
|
作者：
Neklesa, Taavi K. [1 ]
Crews, Craig M. [2 ,3 ]
机构：
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA
[3] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA
来源：
NATURE | 2012年 / 487卷 / 7407期
关键词：
DEGRADATION; LIBRARIES;
D O I：
10.1038/487308a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Most proteins in the human body are difficult targets for small-molecule drugs. This problem may have been overcome with the discovery of molecules that induce protein degradation, suggesting fresh, modular approaches to drug discovery.
引用
收藏
页码：308 / 309
页数：2
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